Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression

被引:2
作者
Hashiguchi, Masaaki [1 ]
Asatsuma-Okumura, Tomoko [1 ]
Iwai, Yoshiko [1 ]
机构
[1] Nippon Med Sch, Inst Adv Med Sci, Grad Sch Med, Dept Cell Biol, 1 1 5 Sendagi,Bunkyo Ku, Tokyo, Japan
基金
日本学术振兴会;
关键词
Class switch; IgE; IgG1; IL-21; Plasma cell; B-CELLS; IL-21;
D O I
10.1002/eji.202451041
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页数:4
相关论文
共 9 条
[1]   Cutting edge:: The common γ-chain is an indispensable subunit of the IL-21 receptor complex [J].
Asao, H ;
Okuyama, C ;
Kumaki, S ;
Ishii, N ;
Tsuchiya, S ;
Foster, D ;
Sugamura, K .
JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :1-5
[2]   IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts [J].
Berglund, Lucinda J. ;
Avery, Danielle T. ;
Ma, Cindy S. ;
Moens, Leen ;
Deenick, Elissa K. ;
Bustamante, Jacinta ;
Boisson-Dupuis, Stephanie ;
Wong, Melanie ;
Adelstein, Stephen ;
Arkwright, Peter D. ;
Bacchetta, Rosa ;
Bezrodnik, Liliana ;
Dadi, Harjit ;
Roifman, Chaim M. ;
Fulcher, David A. ;
Ziegler, John B. ;
Smart, Joanne M. ;
Kobayashi, Masao ;
Picard, Capucine ;
Durandy, Anne ;
Cook, Matthew C. ;
Casanova, Jean-Laurent ;
Uzel, Gulbu ;
Tangye, Stuart G. .
BLOOD, 2013, 122 (24) :3940-3950
[3]   The regulation of immunoglobulin E class-switch recombination [J].
Geha, RS ;
Jabara, HH ;
Brodeur, SR .
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (09) :721-732
[4]   IgE repertoire and immunological memory: compartmental regulation and antibody function [J].
Gould, Hannah J. ;
Wu, Yu-Chang Bryan .
INTERNATIONAL IMMUNOLOGY, 2018, 30 (09) :403-412
[5]   IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses [J].
Harada, Michishige ;
Magara-Koyanagi, Kumiko ;
Watarai, Hiroshi ;
Nagata, Yuko ;
Ishii, Yasuyuki ;
Kojo, Satoshi ;
Horiguchi, Shigetoshi ;
Okamoto, Yoshitaka ;
Nakayama, Toshinori ;
Suzuki, Nobutaka ;
Yeh, Wen-Chen ;
Akira, Shizuo ;
Kitamura, Hiroshi ;
Ohara, Osamu ;
Seino, Ken-ichiro ;
Taniguchi, Masaru .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (13) :2929-2937
[6]   A critical role for IL-21 in regulating immunoglobulin production [J].
Ozaki, K ;
Spolski, R ;
Feng, CG ;
Qi, CF ;
Cheng, J ;
Sher, A ;
Morse, HC ;
Liu, CY ;
Schwartzberg, PL ;
Leonard, WJ .
SCIENCE, 2002, 298 (5598) :1630-1634
[7]  
Stütz AM, 1999, J IMMUNOL, V163, P4383
[8]   IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE [J].
Wang, Shu ;
Wang, Jingya ;
Kumar, Varsha ;
Karnell, Jodi L. ;
Naiman, Brian ;
Gross, Phillip S. ;
Rahman, Saifur ;
Zerrouki, Kamelia ;
Hanna, Richard ;
Morehouse, Christopher ;
Holoweckyj, Nicholas ;
Liu, Hao ;
Manna, Zerai ;
Goldbach-Mansky, Raphaela ;
Hasni, Sarfaraz ;
Siegel, Richard ;
Sanjuan, Miguel ;
Streicher, Katie ;
Cancro, Michael P. ;
Kolbeck, Roland ;
Ettinger, Rachel .
NATURE COMMUNICATIONS, 2018, 9
[9]   IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism [J].
Zotos, Dimitra ;
Coquet, Jonathan M. ;
Zhang, Yang ;
Light, Amanda ;
D'Costa, Kathy ;
Kallies, Axel ;
Corcoran, Lynn M. ;
Godfrey, Dale I. ;
Toellner, Kai-Michael ;
Smyth, Mark J. ;
Nutt, Stephen L. ;
Tarlinton, David M. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (02) :365-378