Alginate-Based hydrogels with inorganic Nanomaterials: A promising approach for wound healing and bone tissue regeneration

Tissue regeneration, particularly in the context of skin and bone, remains a significant challenge in the field of regenerative medicine. Among advanced wound dressing materials and bone scaffolds, alginate gained much attention due to biocompatibility, biodegradability, and tunable properties. However, native alginate hydrogels have limited mechanical strength and cell adhesion properties which are the important parameters for skin and bone tissues regenerations. Inorganic nanomaterials could be incorporated into alginate hydrogels to improve their mechanical strength, cell adhesion, and other properties. This review summarizes the recent advances in alginate-based hydrogels with inorganic nanomaterials for wound healing and bone tissue regeneration. The different types of inorganic nanomaterials that have been incorporated into alginate hydrogels are discussed, along with their effects on the properties and performance of the hydrogels. The various fabrication methods for alginate-based nanohydrogels are also reviewed. The review concludes by highlighting the promising potential of alginate-based nanohydrogels for wound healing and bone tissue regeneration.