Palladium/Xu-Phos Catalyzed Enantioselective Intramolecular Heck Reaction of Unactivated Alkenes

被引：0

作者：

Zhou, Lujia ^{[1
]}

Ma, Longling ^{[1
]}

Xu, Bing ^{[2
]}

Zhang, Zhan-Ming ^{[1
,3
]}

Zhang, Junliang ^{[1
,3
,4
]}

机构：

[1] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China

[2] Zhuhai Fudan Innovat Inst, Zhuhai 519000, Guangdong, Peoples R China

[3] Fudan Zhangjiang Inst, Shanghai 201203, Peoples R China

[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2024年 / 42卷 / 20期

基金：

中国博士后科学基金; 中国国家自然科学基金; 国家重点研发计划;

关键词：

Palladium; Heck; 2,3-Dihydrobenzofuran; Asymmetric catalysis; Quaternary stereocenter; Enantioselective; P ligands; Alkenes; ASYMMETRIC-SYNTHESIS; DIHYDRODEHYDRODICONIFERYL ALCOHOL; CHIRAL LIGAND; DERIVATIVES; FUNCTIONALIZATION; NEOLIGNANS; INDOLES;

D O I：

10.1002/cjoc.202400391

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed, which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research. Its salient features include high yield, excellent chemo- and enantioselectivity, mild conditions, a broad substrate scope as well as versatile transformations of the product. A highly enantioselective palladium-catalyzed intramolecular Heck reaction of ortho-iodophenol-derived allyl ether, which provides an efficient method to synthesize various chiral 3,3-disubstituted 2,3-dihydrobenzofuran compounds bearing an all-carbon quaternary stereocenter has been developed. image

引用

页码：2466 / 2470

页数：5

共 48 条

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