Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

被引:3
|
作者
Karabaeva, Raushan Zh [1 ]
Vochshenkova, Tamara A. [1 ]
Mussin, Nadiar M. [2 ]
Albayev, Rustam K. [1 ]
Kaliyev, Asset A. [2 ]
Tamadon, Amin [3 ,4 ]
机构
[1] Presidents Affairs Adm Republ Kazakhstan, Med Ctr Hosp, Gerontol Ctr, Astana, Kazakhstan
[2] West Kazakhstan Marat Ospanov Med Univ, Gen Surg, Aktobe, Kazakhstan
[3] West Kazakhstan Marat Ospanov Med Univ, Dept Nat Sci, Aktobe, Kazakhstan
[4] PerciaVista R&D Co, Dept Res & Dev, Shiraz, Iran
来源
关键词
coronary artery disease; hypertension; type 2 diabetes mellitus; epigenetics; genetic variation; DNA methylation; histone; modification; DNA METHYLATION; BLOOD-PRESSURE; CARDIAC-HYPERTROPHY; LIFE-STYLE; GENE; MODULATION; EXPRESSION; SALT; PREECLAMPSIA; DEFICIENCY;
D O I
10.3389/fendo.2024.1365738
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM.
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页数:16
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