Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area

被引：3

作者：

Paller, Amy S. ^{[1
,2
]}

Scharschmidt, Tiffany C. ^{[3
]}

Kezic, Sanja ^{[4
]}

Irvine, Alan D. ^{[5
]}

机构：

[1] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, 676North St Clair,Suite 1600, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Pediat, Feinberg Sch Med, 676North St Clair,Suite 1600, Chicago, IL 60611 USA

[3] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA

[4] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Med Ctr, Amsterdam, Netherlands

[5] Trinity Coll Dublin, Clin Med, Dublin, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2024年 / 144卷 / 05期

关键词：

Atopic dermatitis; Biomarkers; Epidermal barrier; Infants; Personalized medicine; TRANSEPIDERMAL WATER-LOSS; STRATUM-CORNEUM; GUT MICROBIOTA; EARLY-LIFE; DIVERSITY; CHILDREN; ECZEMA; FILAGGRIN; EMOLLIENT; BARRIER;

D O I：

10.1016/j.jid.2024.02.021

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Whereas clinically apparent atopic dermatitis (AD) can be confirmed by validated diagnostic criteria, the preclinical phenotype of infants who eventually develop AD is less well -characterized. Analogous to unaffected or nonlesional skin in established AD, clinically normal -appearing skin in infants who will develop clinical AD has distinct changes. Prospective studies have revealed insights into this preclinical AD phenotype. In this study, we review the structural, immunologic, and microbiome nature of the preclinical AD phenotype. Determination of markers that predict the development of AD will facilitate targeting of interventions to prevent the development or reduce the severity of AD in infants.

引用

页码：1001 / 1009

页数：9

共 50 条

[41] Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood [J].

Bager, Peter ;

Wohlfahrt, Jan ;

Thyssen, Jacob Pontoppidan ;

Melbye, Mads .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2016, 27 (02) :162-168

[42] Predicting Skin Barrier Dysfunction and Atopic Dermatitis in Early Infancy [J].

Rehbinder, Eva Maria ;

Endre, Kim M. Advocaat ;

Carlsen, Karin C. Lodrup ;

Asarnoj, Anna ;

Bains, Karen Eline Stensby ;

Berents, Teresa Lovold ;

Carlsen, Kai-Hakon ;

Gudmundsdottir, Hrefna Katrin ;

Haugen, Guttorm ;

Hedlin, Gunilla ;

Kreyberg, Ina ;

Nordhagen, Live Solveig ;

Nordlund, Bjorn ;

Saunders, Carina Madelen ;

Sandvik, Leiv ;

Skjerven, Havard O. ;

Soderhall, Cilla ;

Staff, Anne Cathrine ;

Vettukattil, Riyas ;

Vaernesbranden, Magdalena R. ;

Landro, Linn ;

Carlsen, Monica Hauger ;

Carlsen, Oda C. Lodrup ;

Granlund, Peder Annaeus ;

Granum, Berit ;

Gotberg, Sandra ;

Hilde, Katarina ;

Jonassen, Christine Monceyron ;

Nygaard, Unni C. ;

Rudi, Knut ;

Skrindo, Ingebjorg ;

Sjoborg, Katrine ;

Tedner, Sandra G. ;

Wiik, Johanna ;

Winger, Angelica Johansen ;

Berglind, Ann ;

Despriee, Ashild Wik ;

Essen, Ingvild ;

Fatnes, Thea Aspelund ;

Gudbrandsgard, Malen ;

Kjendsli, Mari Ronning ;

Lunde, Jon ;

Magi, Caroline-Aleksi Olsson ;

Nilsson, Nora ;

Sjelmo, Sigrid ;

Sedergren, Natasha ;

Soderman, Paivi ;

Tegnerud, Ellen .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2020, 8 (02) :664-+

[43] Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification [J].

Huelpuesch, Claudia ;

Rohayem, Robin ;

Reiger, Matthias ;

Traidl-Hoffmann, Claudia .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 154 (01) :31-41

[44] Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis [J].

Mikhaylov, Daniela ;

Del Duca, Ester ;

Guttman-Yassky, Emma .

EXPERT REVIEW OF PROTEOMICS, 2021, 18 (05) :345-361

[45] Research Progress on the Correlation of Atopic Dermatitis with Gut Microbiota [J].

Mao, Qiuyu ;

Wang, Xinyi ;

Cai, Haibin ;

Yang, Jingyi ;

Zhang, Yiwen ;

Min, Wei ;

Qian, Qihong ;

Zeng, Yibin .

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2024, 17 :1613-1619

[46] Significance of Skin Barrier Dysfunction in Atopic Dermatitis [J].

Kim, Byung Eui ;

Leung, Donald Y. M. .

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2018, 10 (03) :207-215

[47] Is the skin barrier abnormal in dogs with atopic dermatitis? [J].

Olivry, Thierry .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2011, 144 (1-2) :11-16

[48] Managing Atopic Dermatitis in Patients With Skin of Color [J].

Davis, Carla M. ;

Flohr, Carsten ;

Gupta, Meera R. ;

Koplin, Jennifer J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2023, 11 (05) :1376-1383

[49] Skin Infections in Atopic Dermatitis: Treatment Challenges [J].

Sung, Myongsoon ;

Kim, Byung Eui ;

Leung, Donald Y. M. .

CURRENT TREATMENT OPTIONS IN ALLERGY, 2025, 12 (01)

[50] Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy [J].

Yamamoto-Hanada, Kiwako ;

Kobayashi, Tohru ;

Mikami, Masashi ;

Williams, Hywel C. ;

Saito, Hirohisa ;

Saito-Abe, Mayako ;

Sato, Miori ;

Irahara, Makoto ;

Miyaji, Yumiko ;

Ishikawa, Fumi ;

Tsuchiya, Kunihiko ;

Tamagawa-Mineoka, Risa ;

Takaoka, Yuri ;

Takemura, Yutaka ;

Sato, Sakura ;

Wakiguchi, Hiroyuki ;

Hoshi, Miyuki ;

Natsume, Osamu ;

Yamaide, Fumiya ;

Seike, Miwako ;

Ohya, Yukihiro .

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