Feasibility study of focused ultrasound in the treatment of vulvar low-grade squamous intraepithelial lesions with persistent symptoms

被引:0
作者
Su, Chang [1 ,2 ]
Liu, Xinglin [1 ,2 ]
Wu, Can [3 ]
Wang, Xi [1 ,2 ]
Li, Chengzhi [1 ,2 ]
机构
[1] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China
[3] Chongqing Haifu Hosp, Dept Gynecol, Chongqing, Peoples R China
关键词
Focused ultrasound; vulvar low-grade squamous intraepithelial lesions; feasibility; efficacy; safety; NONNEOPLASTIC EPITHELIAL DISORDERS; HUMAN-PAPILLOMAVIRUS; NEOPLASIA; THERAPY; EFFICACY; RESPONSES;
D O I
10.1080/02656736.2024.2365975
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: This study aimed to investigate the feasibility, efficacy, and safety of focused ultrasound (FUS) for the treatment of vulvar low-grade squamous intraepithelial lesions (VLSIL) with persistent symptoms. Methods: This retrospective analysis included 24 VLSIL patients who underwent FUS treatment. At each follow-up visit, the clinical response was assessed including changes in symptoms and signs. In addition, the histological response was assessed based on the vulvar biopsy results of the 3rd follow-up. Clinical and histological response were assessed to elucidate the efficacy. Results: A total of 22 patients completed follow-up and post-treatment pathological biopsies. After treatment, the clinical scores of itching decreased from 2.55 +/- 0.51 to 0.77 +/- 0.81 (p < 0.05). Furthermore, the clinical response rate and histological response rate were 86.4% and 81.8%, respectively. Only two cured patients indicated recurrence in the 3rd and 4th year during the follow-up period and achieved cure after re-treatment. In terms of adverse effects, only one patient developed ulcers after treatment, which healed after symptomatic anti-inflammatory treatment without scarring, and no other treatment complications were found in any patients. None of the patients developed a malignant transformation during the follow-up period. Conclusion: This study revealed that FUS is feasible, effective, and safe for treating VLSIL patients with persistent symptoms, providing a new solution for the noninvasive treatment of symptomatic VLSIL.
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页数:6
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