Type 2 airway inflammation in COPD

被引：10

作者：

Polverino, Francesca ^{[1
]}

Sin, Don D. ^{[2
,3
]}

机构：

[1] Baylor Coll Med, Dept Med, Pulm & Crit Care Med, Houston, TX USA

[2] St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada

[3] Univ British Columbia, Div Resp Med, Vancouver, BC, Canada

来源：

EUROPEAN RESPIRATORY JOURNAL | 2024年 / 63卷 / 05期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; SEVERE UNCONTROLLED ASTHMA; INNATE LYMPHOID-CELLS; DOUBLE-BLIND; SPUTUM EOSINOPHILIA; LUNG INFLAMMATION; PHASE; 2A; HYPERRESPONSIVENESS; TEZEPELUMAB; CYTOKINES;

D O I：

10.1183/13993003.00150-2024

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Globally, nearly 400 million persons have COPD, and COPD is one of the leading causes of hospitalisation and mortality across the world. While it has been long-recognised that COPD is an inflammatory lung disease, dissimilar to asthma, type 2 inflammation was thought to play a minor role. However, recent studies suggest that in approximately one third of patients with COPD, type 2 inflammation may be an important driver of disease and a potential therapeutic target. Importantly, the immune cells and molecules involved in COPD-related type 2 immunity may be significantly different from those observed in severe asthma. Here, we identify the important molecules and effector immune cells involved in type 2 airway inflammation in COPD, discuss the recent therapeutic trial results of biologicals that have targeted these pathways and explore the future of therapeutic development of type 2 immune modulators in COPD.

引用

页数：12

共 92 条

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