HIV-associated Burkitt lymphoma in the combination antiretroviral therapy era: Real-world outcomes and prognostication

被引:5
作者
Wang, Chaoyu [1 ]
Liang, Shunsi [1 ]
Quan, Xi [1 ]
Guo, Bingling [1 ]
Huang, Dehong [1 ]
Li, Jieping [1 ]
Liu, Yao [1 ]
机构
[1] Chongqing Univ, Dept Hematol Oncol, Chongqing Key Lab Translat Res Canc Metastasis & I, Canc Hosp, Chongqing 400030, Peoples R China
来源
EJHAEM | 2023年 / 4卷 / 01期
基金
中国国家自然科学基金;
关键词
Burkitt's lymphoma; clinical characteristics; HIV; outcomes; prognostication; CODOX-M/IVAC; INTENSIVE CHEMOTHERAPY; CYCLOPHOSPHAMIDE; DOXORUBICIN; RITUXIMAB;
D O I
10.1002/jha2.624
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We performed a retrospective study to analyze the clinical characteristics and outcomes of human immunodeficiency virus-associated Burkitt's lymphoma in Chongqing University Cancer Hospital, southwest China, from March 2012 to February 2022. In the entire cohort, the median age was 36 years (range, 28-60 years), and more patients were male (82.4%). The median CD4(+) T cell count was 214/mu l (range, 54-601), of whom 47.1% had a CD4(+) T cell count below 200/mu l. Most patients had elevated lactate dehydrogenase (LDH), elevated beta(2)-MG, extranodal involvement and advanced Ann Arbor stage at diagnosis. With a median follow-up of 11.5 months (range, 1.6-94.9 months), the overall 1-year progression-free survival and overall survival (OS) rates were 27.6% and 47.6%, respectively. The 1-year OS times in the LDH < 3 upper limit of normal and LDH >= 3 upper limit of normal groups were 62.5% and 31.3%, respectively (p = 0.008). The 1-year OS times in the received <4 cycles and >= 4 cycles groups were 0% and 77.8%, respectively (p < 0.001). These results demonstrated that LDH < 3 upper limit of normal and received >= 4 cycles of chemotherapy were significantly associated with improved outcomes. However, rituximab administration was not significantly associated with improved outcomes.
引用
收藏
页码:100 / 107
页数:8
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