Recent advances of honokiol:pharmacological activities, manmade derivatives and structure-activity relationship

被引：11
作者：
Li, Xiuxia [1 ]
Yuan, Zhuo [2 ]
Wang, Yuxia [3 ]
Wang, Wenjing [4 ,5 ,6 ]
Shi, Jianyou [1 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sch Med, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Geriatr Med Ctr, Geriatr Intens Care Unit, Chengdu 610072, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Peoples R China
[5] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[6] Sichuan Univ, West China Hosp, West China Med Publishers, Chengdu 610041, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 272卷
基金：
中国国家自然科学基金;
关键词：
Honokiol (HNK); Antitumor activity; Derivatives; Structural modification; Structure-activity relationship (SAR); SQUAMOUS-CELL CARCINOMA; MAGNOLIA-OFFICINALIS; HONOKIOL DERIVATIVES; LUNG-CANCER; IN-VIVO; ANALOGS; ANGIOGENESIS; APOPTOSIS; GROWTH; BARK;
D O I：
10.1016/j.ejmech.2024.116471
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Honokiol (HNK) is a typical natural biphenyl polyphenol compound. It has been proven to have a wide range of biological activities, including pharmacological effects such as anti-cancer, anti-inflammatory, neuroprotective, and antimicrobial. However, due to the poor stability, water solubility, and bioavailability of HNK, HNK has not been used in clinical treatment. This article reviews the latest research on the pharmacological activity of HNK and summarizes the HNK derivatives designed and improved by several researchers. Reviewing these contents could promote the research process of HNK and guide the design of better HNK derivatives for clinical application in the future.
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页数：16
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