Advances in Nasopharyngeal Carcinoma Treatment: Induction Chemotherapy and Concomitant Radio-Chemotherapy

被引:0
作者
Carvajal, Felipe [1 ,2 ]
Luyo, Gustavo [3 ]
Veloso, Javier [6 ]
Veloso, Marcelo [4 ]
Alarcon, Freddy [1 ]
Villa, Eduardo [7 ]
Saavedra, Erika [5 ]
机构
[1] Inst Nacl Canc, Serv Radioterapia Oncol, Santiago, Chile
[2] Univ Chile, Dept Oncol Basico Clin, Fac Med, Santiago, Chile
[3] Oncosalud AUN, Dept Radioterapia Oncol, Lima, Peru
[4] Inst Nacl Canc, Serv Cirugia Cabeza & Cuello, Santiago, Chile
[5] Inst Nacl Canc, Serv Oncol Med, Santiago, Chile
[6] Univ Los Andes, Med, Santiago, Chile
[7] Univ Chile, Fac Med, Med, Santiago, Chile
关键词
Chemoradiotherapy; Drug Therapy; Nasopharyngeal Carcinoma; Radiotherapy; INTENSITY-MODULATED RADIOTHERAPY; LOCALLY ADVANCED HEAD; CONVENTIONAL 2-DIMENSIONAL RADIOTHERAPY; COMPARING NEOADJUVANT CHEMOTHERAPY; PLUS ADJUVANT CHEMOTHERAPY; QUALITY-OF-LIFE; PHASE-III TRIAL; RANDOMIZED-TRIAL; CONCURRENT CHEMORADIOTHERAPY; TREATMENT OUTCOMES;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Squamous cell carcinoma of the nasopharynx is responsible for 0.7% of all malignant tumors worldwide, with the highest incidence in the population of southern China and Southeast Asia. The standard treatment for locally advanced disease consists of a combination of radiotherapy and chemotherapy in different schedules. Among them, induction chemotherapy followed by concomitant radio-chemotherapy has shown in recent years to be a standard therapeutic option with high rates of locoregional control and overall survival. This paper aims to review the current evidence related to treatment with induction chemotherapy and subsequent radio-chemotherapy in nasopharyngeal cancer, its effectiveness, and the technical aspects of its applicability.
引用
收藏
页码:1221 / 1232
页数:12
相关论文
共 56 条
[1]   Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized intergroup study 0099 [J].
Al-Sarraf, M ;
LeBlanc, M ;
Giri, PGS ;
Fu, KK ;
Cooper, J ;
Vuong, T ;
Forastiere, AA ;
Adams, G ;
Sakr, WA ;
Schuller, DE ;
Ensley, JF .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (04) :1310-1317
[2]  
Aw L, 2019, Int J Radiat Oncol Biol Phys Internet, V105
[3]   Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group [J].
Blanchard, Pierre ;
Bourhis, Jean ;
Lacas, Benjamin ;
Posner, Marshall R. ;
Vermorken, Jan B. ;
Cruz Hernandez, Juan J. ;
Bourredjem, Abderrahmane ;
Calais, Gilles ;
Paccagnella, Adriano ;
Hitt, Ricardo ;
Pignon, Jean-Pierre .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (23) :2854-+
[4]   Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].
Bossi, P. ;
Chan, A. T. ;
Licitra, L. ;
Trama, A. ;
Orlandi, E. ;
Hui, E. P. ;
Halamkova, J. ;
Mattheis, S. ;
Baujat, B. ;
Hardillo, J. ;
Smeele, L. ;
van Herpen, C. ;
Castro, A. ;
Machiels, J-P .
ANNALS OF ONCOLOGY, 2021, 32 (04) :452-465
[5]   Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a phase III randomized trial [J].
Chan, ATC ;
Teo, PML ;
Ngan, RK ;
Leung, TW ;
Lau, WH ;
Zee, B ;
Leung, SF ;
Cheung, FY ;
Yeo, W ;
Yiu, HH ;
Yu, KH ;
Chiu, KW ;
Chan, DT ;
Mok, T ;
Yuen, KT ;
Mo, F ;
Lai, M ;
Kwan, WH ;
Choi, P ;
Johnson, PJ .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (08) :2038-2044
[6]   Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial [J].
Chen, Lei ;
Hu, Chao-Su ;
Chen, Xiao-Zhong ;
Hu, Guo-Qing ;
Cheng, Zhi-Bin ;
Sun, Yan ;
Li, Wei-Xiong ;
Chen, Yuan-Yuan ;
Xie, Fang-Yun ;
Liang, Shao-Bo ;
Chen, Yong ;
Xu, Ting-Ting ;
Li, Bin ;
Long, Guo-Xian ;
Wang, Si-Yang ;
Zheng, Bao-Min ;
Guo, Ying ;
Sun, Ying ;
Mao, Yan-Ping ;
Tang, Ling-Long ;
Chen, Yu-Ming ;
Liu, Meng-Zhong ;
Ma, Jun .
LANCET ONCOLOGY, 2012, 13 (02) :163-171
[7]   Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline [J].
Chen, Yu-Pei ;
Ismaila, Nofisat ;
Chua, Melvin L. K. ;
Colevas, A. Dimitrios ;
Haddad, Robert ;
Huang, Shao Hui ;
Wee, Joseph T. S. ;
Whitley, Alexander C. ;
Yi, Jun-Lin ;
Yom, Sue S. ;
Chan, Anthony T. C. ;
Hu, Chao-Su ;
Lang, Jin-Yi ;
Le, Quynh-Thu ;
Lee, Anne W. M. ;
Lee, Nancy ;
Lin, Jin-Ching ;
Ma, Brigette ;
Morgan, Thomas J. ;
Shah, Jatin ;
Sun, Ying ;
Ma, Jun .
JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (07) :840-+
[8]   Nasopharyngeal carcinoma [J].
Chen, Yu-Pei ;
Chan, Anthony T. C. ;
Quynh-Thu Le ;
Blanchard, Pierre ;
Sun, Ying ;
Ma, Jun .
LANCET, 2019, 394 (10192) :64-80
[9]  
Chua DTT, 1998, CANCER, V83, P2270, DOI 10.1002/(SICI)1097-0142(19981201)83:11<2270::AID-CNCR6>3.3.CO
[10]  
2-K