Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities

被引:3
作者
Valdez, Caroline Naomi [1 ]
Sanchez-Zuno, Gabriela Athziri [2 ]
Bucala, Richard [1 ,2 ,3 ]
Tran, Thuy T. [1 ,3 ,4 ]
机构
[1] Yale Univ, Sch Med, 333 Cedar St, New Haven, CT 06510 USA
[2] Yale Univ, Dept Internal Med, Sect Rheumatol Allergy & Immunol, 333 Cedar St, New Haven, CT 06510 USA
[3] Yale Univ, Yale Canc Ctr, 333 Cedar St, New Haven, CT 06510 USA
[4] Yale Univ, Dept Internal Med, Sect Med Oncol, 333 Cedar St, New Haven, CT 06510 USA
关键词
Macrophage Migratory Inhibition Factor; MIF; D-dopachrome tautomerase; DDT; cytokines; cancer; oncology; CHRONIC LYMPHOCYTIC-LEUKEMIA; SQUAMOUS-CELL CARCINOMA; GASTRIC EPITHELIAL-CELLS; PROSTATE-CANCER CELLS; INCREASED EXPRESSION; GENE POLYMORPHISMS; COLORECTAL-CANCER; SIGNALING PATHWAY; MELANOMA-CELLS; PROMOTER POLYMORPHISMS;
D O I
10.3390/ijms25094849
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Discovered as inflammatory cytokines, MIF and DDT exhibit widespread expression and have emerged as critical mediators in the response to infection, inflammation, and more recently, in cancer. In this comprehensive review, we provide details on their structures, binding partners, regulatory mechanisms, and roles in cancer. We also elaborate on their significant impact in driving tumorigenesis across various cancer types, supported by extensive in vitro, in vivo, bioinformatic, and clinical studies. To date, only a limited number of clinical trials have explored MIF as a therapeutic target in cancer patients, and DDT has not been evaluated. The ongoing pursuit of optimal strategies for targeting MIF and DDT highlights their potential as promising antitumor candidates. Dual inhibition of MIF and DDT may allow for the most effective suppression of canonical and non-canonical signaling pathways, warranting further investigations and clinical exploration.
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页数:24
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