Recent advances in scaffold based electrospun for breast cancer research

被引:3
作者
Ebrahimbaygi, Parya [1 ]
Khazaei, Mohammad Rasool [2 ,3 ]
Valadbeigi, Parham [1 ]
Rostaminasab, Gelavizh [4 ,5 ,6 ]
Mikaeili, Abdolhamid [7 ]
Jouybari, Touraj Ahmadi [4 ,5 ,6 ]
Rezakhani, Leila [2 ,3 ]
机构
[1] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Hlth Technol Inst, Fertil & Infertil Res Ctr, Kermanshah, Iran
[3] Kermanshah Univ Med Sci, Sch Med, Dept Tissue Engn, St Shahid Shiroudi Blvd, Kermanshah 6714869914, Iran
[4] Kermanshah Univ Med Sci, Imam Khomeini Hosp, Clin Res Dev Ctr, Kermanshah, Iran
[5] Kermanshah Univ Med Sci, Mohammad Kermanshahi Hosp, Clin Res Dev Ctr, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Farabi Hosp, Clin Res Dev Ctr, Kermanshah, Iran
[7] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah, Iran
关键词
3D model; breast cancer; electrospun; scaffold; DRUG-DELIVERY; STEM-CELLS; CONTROLLED-RELEASE; ANTICANCER DRUG; TUMOR-MODEL; NANO-FIBER; NANOFIBERS; CULTURE; PARAMETERS; MEMBRANES;
D O I
10.1002/pat.6499
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
One of the biggest challenges facing public health in the modern era is the management of cancer, a global health issue. Breast cancer (BC) is the most common malignancy among women worldwide. Among the most popular cancer treatment modalities are radiation, chemotherapy, and surgery. Chemotherapy, however, is regarded as the primary treatment option for cancer that has progressed to the final and metastatic stages. However, because of things like toxicity to healthy cells, poor drug absorption, trouble getting drugs to target tumor sites, and low therapeutic efficacy, traditional chemotherapy approaches are frequently insufficient. Nanotechnology offers the potential to overcome some of these limitations by creating new materials with unique properties through electrospinning. A straightforward and reasonably priced technique for creating biomaterials that can replicate the topography and structure of the cellular matrix is electrospinning. These materials have a large surface area, can be mechanically controlled, and have a level of fibers that can be adjusted from micrometers to nanometers. This review article emphasizes the potential of electrospun scaffolds for the treatment of BC while also offering a basic understanding of the procedure and nanostructured fibrous materials. This article reviews the most recent emerging electrospinning techniques in BC therapy. First, it briefly introduces the progress made in electrospinning in BC research over the past few years. Next, it investigates electrospinning by summarizing the techniques and materials used in the process. In addition, it demonstrates how crucial electrospinning three-dimensional (3D) models are for the diagnosis and treatment of BC. This article also clarifies numerous electrospinning uses in several fields, such as cell culture, drug delivery, drug loading, and gene therapy. The final section discusses the advantages, limitations, and challenges electrospinning is willing to encounter in BC research.
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页数:17
相关论文
共 149 条
[11]   In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions [J].
Boelgen, N. ;
Vargel, I. ;
Korkusuz, P. ;
Menceloglu, Y. Z. ;
Piskin, E. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2007, 81B (02) :530-543
[12]   Acetone, a Sustainable Solvent for Electrospinning Poly(ε-Caprolactone) Fibres: Effect of Varying Parameters and Solution Concentrations on Fibre Diameter [J].
Bosworth, Lucy A. ;
Downes, Sandra .
JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2012, 20 (03) :879-886
[13]   Evaluating protein incorporation and release in electrospun composite scaffolds for bone tissue engineering applications [J].
Briggs, Tonye ;
Matos, Jeffrey ;
Collins, George ;
Arinzeh, Treena Livingston .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2015, 103 (10) :3117-3127
[14]   Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system [J].
Bulbul, Y. Emre ;
Okur, Mujgan ;
Demirtas-Korkmaz, Funda ;
Dilsiz, Nursel .
APPLIED CLAY SCIENCE, 2020, 186
[15]  
Buzgo M, 2018, WOODH PUBL SER BIOM, P325, DOI 10.1016/B978-0-08-102198-9.00011-9
[16]   Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy [J].
Cavo, Marta ;
Serio, Francesca ;
Kale, Narendra R. ;
D'Amone, Eliana ;
Gigli, Giuseppe ;
del Mercato, Loretta L. .
BIOMATERIALS SCIENCE, 2020, 8 (18) :4887-4905
[17]   A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed "in vivo" [J].
Cavo, Marta ;
Caria, Marco ;
Pulsoni, Ilaria ;
Beltrame, Francesco ;
Fato, Marco ;
Scaglione, Silvia .
SCIENTIFIC REPORTS, 2018, 8
[18]   Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature [J].
Charafe-Jauffret, Emmanuelle ;
Ginestier, Christophe ;
Iovino, Flora ;
Wicinski, Julien ;
Cervera, Nathalie ;
Finetti, Pascal ;
Hur, Min-Hee ;
Diebel, Mark E. ;
Monville, Florence ;
Dutcher, Julie ;
Brown, Marty ;
Viens, Patrice ;
Xerri, Luc ;
Bertucci, Francois ;
Stassi, Giorgio ;
Dontu, Gabriela ;
Birnbaum, Daniel ;
Wicha, Max S. .
CANCER RESEARCH, 2009, 69 (04) :1302-1313
[19]   S100β as a serum marker in endocrine resistant breast cancer [J].
Charmsaz, Sara ;
Hughes, Eamon ;
Bane, Fiona T. ;
Tibbitts, Paul ;
McIlroy, Marie ;
Byrne, Christopher ;
Cocchiglia, Sinead ;
McBryan, Jean ;
Hennessy, Bryan T. ;
Dwyer, Roisin M. ;
Kerin, Michael J. ;
Hill, Arnold D. ;
Young, Leonie S. .
BMC MEDICINE, 2017, 15
[20]   Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review [J].
Chaudhari, Atul A. ;
Vig, Komal ;
Baganizi, Dieudonne Rade ;
Sahu, Rajnish ;
Dixit, Saurabh ;
Dennis, Vida ;
Singh, Shree Ram ;
Pillai, Shreekumar R. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (12)