Biomaterials in heterotopic ossification: Prophylaxis and promotion

被引：1

作者：

Lou, Xu ^{[1
]}

Huang, Dan ^{[2
,4
]}

Li, Guangfeng ^{[2
,4
,6
,7
]}

Bai, Long ^{[2
,4
,5
]}

Su, Jiacan ^{[2
,3
,4
]}

Yue, Hua ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Clin Res Ctr Bone Dis, Sch Med, Dept Osteoporosis & Bone Dis, Shanghai 200233, Peoples R China

[2] Shanghai Univ, Inst Translat Med, Organoid Res Ctr, Shanghai 200444, Peoples R China

[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Orthoped, Shanghai 200092, Peoples R China

[4] Shanghai Univ, Natl Ctr Translat Med, Shanghai SHU Branch, Shanghai 200444, Peoples R China

[5] Shanghai Univ, Wenzhou Inst, Wenzhou 325000, Peoples R China

[6] Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China

[7] Shanghai Zhongye Hosp, Dept Orthoped, Shanghai 200444, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2024年 / 497卷

基金：

中国国家自然科学基金;

关键词：

Heterotopic ossification; Biomaterials; Prophylaxis; Promotion; Bone regeneration; ECTOPIC BONE-FORMATION; NANO-HYDROXYAPATITE; IN-VIVO; OSTEOINDUCTION; PREVENTS; CELLS; OSTEOGENESIS; INHIBITION; METABOLISM; MANAGEMENT;

D O I：

10.1016/j.cej.2024.153811

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Heterotopic ossification (HO) is an abnormal bone formation within non-skeletal tissues, impairing daily functionality and significantly diminishing patient quality of life. This condition presents serious clinical challenges, not only due to its impact on mobility and pain but also due to the complexities involved in its management and treatment. Interestingly, the phenomenon of ectopic bone formation, central to HO, also offers a unique avenue in tissue engineering for the constructive repair of complex bone defects. The exploration of biomaterials in this context reveals a dual potential: they can inhibit unwanted bone growth in HO and strategically direct bone formation to heal skeletal injuries. This review systematically summarizes the applications of biomaterials in preventing HO and promoting ectopic ossification to repair bone defects. It also looks forward to the application of emerging technologies such as artificial intelligence and bio-responsive materials in enhancing ectopic bone formation, providing new perspectives for research in bone tissue engineering and expanding the horizons for innovation and application of biomaterials.

引用

页数：20

共 165 条

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