Cognitive Effects of Toxoplasma and CMV Infections: A Cross-Sectional Study of 557 Young Adults Considering Modulation by Sex and Rh Factor

被引：3

作者：

Flegr, Jaroslav ^{[1
]}

Chvatalova, Veronika ^{[1
]}

Priplatova, Lenka ^{[1
]}

Turecek, Petr ^{[1
]}

Kodym, Petr ^{[2
]}

Sebankova, Blanka ^{[1
]}

Kankova, Sarka ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Sci, Dept Philosophy & Hist Sci, Lab Evolutionary Biol, Vinicna 7, Prague 12800, Czech Republic

[2] Natl Reference Lab Toxoplasmosis, Srobarova 48, Prague 10042, Czech Republic

来源：

PATHOGENS | 2024年 / 13卷 / 05期

关键词：

Rh factor; toxoplasmosis; cytomegalovirus; cognition; intelligence; memory; psychomotor performance; parasite; behavior; manipulation hypothesis; CYTOMEGALOVIRUS-INFECTION; PERSISTENT INFECTION; PERSONALITY PROFILE; GONDII; IMPAIRMENT; PERFORMANCE; SEROPOSITIVITY; SEROPREVALENCE; DIAGNOSIS; PROTEINS;

D O I：

10.3390/pathogens13050363

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One-third of humanity harbors a lifelong infection with Toxoplasma gondii, and probably about 80% are infected with human cytomegalovirus (CMV). This study aims to delineate the associations between toxoplasmosis and cognitive abilities and compare these to the associations with CMV. We evaluated the cognitive performance of 557 students, who had been examined for Toxoplasma and CMV infections, using intelligence, memory, and psychomotor tests. The results indicated cognitive impairments in seropositive individuals for both pathogens, with variations in cognitive impact related to sex and the Rh factor. Specifically, Toxoplasma infection was associated with lower IQ in men, whereas CMV was predominantly associated with worse performance by women when testing memory and reaction speeds. Analysis of the antibody concentrations indicated that certain Toxoplasma-associated cognitive detrimental effects may wane (impaired intelligence) or worsen (impaired reaction times) over time following infection. The findings imply that the cognitive impairments caused by both neurotropic pathogens are likely due to pathological changes in the brain rather than from direct manipulative action by the parasites.

引用

页数：22

共 70 条

[1] Persistent infection, inflammation, and functional impairment in older Latinos [J].

Aiello, Allison E. ;

Haan, Mary N. ;

Pierce, Christine M. ;

Simanek, Amanda M. ;

Liang, Jersey .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2008, 63 (06) :610-618

[2] The influence of latent viral infection on rate of cognitive decline over 4 years [J].

Aiello, Allison E. ;

Haan, Mary N. ;

Blythe, Lynn ;

Moore, Kari ;

Gonzalez, Jeffrey M. ;

Jagust, William .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2006, 54 (07) :1046-1054

[3]

Amthauer R., 2001, Der Intelligenz-Struktur-Test 2000R: Manual [The Intelligence-Structure-Test 2000R: Manual]

[4] Cytomegalovirus infection and IQ in patients with severe mental illness and healthy individuals [J].

Andreou, Dimitrios ;

Jogensen, Kjetil Nordb ;

Wortinger, Laura A. ;

Engen, Kristine ;

Vaskinn, Anja ;

Ueland, Torill ;

Yolken, Robert H. ;

Andreassen, Ole A. ;

Agartz, Ingrid .

PSYCHIATRY RESEARCH, 2021, 300

[5] Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals [J].

Barnes, Lisa L. ;

Capuano, Ana W. ;

Aiello, Alison E. ;

Turner, Arlener D. ;

Yolken, Robert H. ;

Torrey, E. Fuller ;

Bennett, David A. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (02) :230-237

[6] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[7] Fatal attraction in rats infected with Toxoplasma gondii [J].

Berdoy, M ;

Webster, JP ;

Macdonald, DW .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2000, 267 (1452) :1591-1594

[8] Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection [J].

Cannon, Michael J. ;

Schmid, D. Scott ;

Hyde, Terri B. .

REVIEWS IN MEDICAL VIROLOGY, 2010, 20 (04) :202-213

[9] The earliest history of eukaryotic life: uncovering an evolutionary story through the integration of biological and geological data [J].

Cohen, Phoebe A. ;

Kodner, Robin B. .

TRENDS IN ECOLOGY & EVOLUTION, 2022, 37 (03) :246-256

[10] Association of Toxoplasma gondii Seropositivity With Cognitive Function in Healthy People A Systematic Review and Meta-analysis [J].

de Haan, Lies ;

Sutterland, Arjen L. ;

Schotborgh, Jasper, V ;

Schirmbeck, Frederike ;

de Haan, Lieuwe .

JAMA PSYCHIATRY, 2021, 78 (10) :1103-1112

← 1 2 3 4 5 6 7 →