Improving resource use efficiency through optimized nitrogen (N) management is the key to increasing crop productivity, but it remains unclear whether integrated N management practices could better improve wheat yield and the use of N and water. Here we investigated the effects of individual and integrated N management practices on wheat production in different soil-climatic conditions, and constructed the relationship between the soil-climate factors and N application rate on wheat yield. Results showed that individual N management practice (optimized N application rate only) reduced wheat yield by 2.4 %, increased N use efficiency (NUE) by 45 %, and decreased water use efficiency (WUE) by 2.2 %; however, integrated N management practice (integrating optimized N rate with irrigation, tillage, manure, or straw return) increased yield and NUE on average by 5.4 % and 55 % respectively, without reducing WUE. In different soil-climate conditions, individual N management practice decreased wheat yield from 1.1 % to 5.0 %; however, integrated N management practice increased yield by 8.5 %, 6.4 %, and 5.8 % in soil organic carbon (SOC) >= 10 g kg(-1), mean annual precipitation <= 400 mm, and 10 degrees C < mean annual temperature <= 15 degrees C, respectively. Mixed-effects model showed that the integrated N management practice had a higher yield by better exploiting the yield-enhancing benefits of SOC. Facing the complex production environment of the future, applying integrated N management practice will be a key alternative for improving grain production and resource use efficiency.