Plant-mediated synthesis and interaction of ZnO against breast and prostate cancer: Review

Recently Nanoparticles (NP) of Zinc Oxide has been obtained from Green Synthesis increasing their knowledge, studying their characteristics and capabilities, due to obtaining process. The reason for understanding ZnO NP using the green method is their interaction with cancer cells. It was observed that in the green process, some compounds can join ZnO NP without affecting their structure, but at the same time can bring about certain features that permit the addition of more tools to act against cancer cells, such as breast and prostate cancer. It is important to mention that breast and prostate cancers are in first and second place, respectively, in the International Agency for Research on Cancer (IACR); therefore, it is crucial to understand the mechanisms of ZnO NP. The principal method of killing cancer cells using ZnO NPs is apoptosis, which can be induced by mitochondrial damage, DNA damage, activation of caspases, anti-inflammatory effects, and oxidative stress. This review is important because it reveals similar pathways and mechanisms through which ZnO NP induce apoptosis and damage in breast and prostate cancer cells. It is important to observe this relationship between inorganic NP synthesized by the green method to improve their activity against cancer cells and discover a route to kill them, demonstrating an increase in the development of a treatment option.