Contemporary Role of Lymph Node Dissection in Genitourinary Cancers: Where Are We in 2023?

Context: Lymphadenectomy during surgery for genitourinary malignancies has varying benefits. Objective: To review contemporary evidence on lymph node dissection in genitourinary cancers. Evidence acquisition: We performed a collaborative review to summarize current evidence supporting lymph node dissection in urothelial, prostate, kidney, penile, and testis cancers. We present the evidence on patient selection and recommended dissection templates, and highlight knowledge gaps and ongoing areas of investigation. Evidence synthesis: Lymph node dissection remains the reference standard for lymph node staging. Pathologic nodal stage informs prognosis and guides adjuvant treatment. Appropriate template and patient selection are paramount to optimize outcomes and capitalize on the selective therapeutic benefits. Conclusions: Accurate staging with lymphadenectomy is contingent on appropriate template selection. The cumulative benefit will depend on judicious patient selection. Patient summary: We performed a collaborative review by a diverse group of experts in urology. We reviewed current evidence on lymph node dissection. (c) 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.