Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer-A Narrative Review

被引：9

作者：

Bakinowska, Estera ^{[1
]}

Kielbowski, Kajetan ^{[1
]}

Skorka, Patryk ^{[1
]}

Dach, Aleksandra ^{[1
]}

Olejnik-Wojciechowska, Joanna ^{[1
]}

Szwedkowicz, Agata ^{[1
]}

Pawlik, Andrzej ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 10期

关键词：

gastric cancer; non-coding RNA; microRNA; long non-coding RNA; circular RNA; biomarkers; PROMOTES CELL-PROLIFERATION; CIRCULAR RNA; CISPLATIN RESISTANCE; POTENTIAL BIOMARKERS; SIGNALING PATHWAY; DIAGNOSTIC BIOMARKER; TUMOR PROLIFERATION; EXPRESSION PROFILE; INVASION; SERUM;

D O I：

10.3390/ijms25105144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs (ncRNAs) represent a broad family of molecules that regulate gene expression, including microRNAs, long non-coding RNAs and circular RNAs, amongst others. Dysregulated expression of ncRNAs alters gene expression, which is implicated in the pathogenesis of several malignancies and inflammatory diseases. Gastric cancer is the fifth most frequently diagnosed cancer and the fourth most common cause of cancer-related death. Studies have found that altered expression of ncRNAs may contribute to tumourigenesis through regulating proliferation, apoptosis, drug resistance and metastasis. This review describes the potential use of ncRNAs as diagnostic and prognostic biomarkers. Moreover, we discuss the involvement of ncRNAs in the pathogenesis of gastric cancer, including their interactions with the members of major signalling pathways.

引用

页数：27

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