Electronic nose based analysis of exhaled volatile organic compounds spectrum reveals asthmatic shifts and consistency in controls post-exercise and spirometry

被引:2
作者
Dragonieri, Silvano [1 ]
Di Marco, Marcin [1 ]
Ahroud, Madiha [1 ]
Quaranta, Vitaliano Nicola [1 ]
Portacci, Andrea [1 ]
Iorillo, Ilaria [1 ]
Montagnolo, Francesca [1 ]
Carpagnano, Giovanna Elisiana [1 ]
机构
[1] Univ Bari, Resp Dis, Bari, Italy
关键词
breath test; biomarkers; asthma; volatile organic compounds; exhaled breath; DISEASE;
D O I
10.1088/1752-7163/ad5864
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Analyzing exhaled volatile organic compounds (VOCs) with an electronic nose (e-nose) is emerging in medical diagnostics as a non-invasive, quick, and sensitive method for disease detection and monitoring. This study investigates if activities like spirometry or physical exercise affect exhaled VOCs measurements in asthmatics and healthy individuals, a crucial step for e-nose technology's validation for clinical use. The study analyzed exhaled VOCs using an e-nose in 27 healthy individuals and 27 patients with stable asthma, before and after performing spirometry and climbing five flights of stairs. Breath samples were collected using a validated technique and analyzed with a Cyranose 320 e-nose. In healthy controls, the exhaled VOCs spectrum remained unchanged after both lung function test and exercise. In asthmatics, principal component analysis and subsequent discriminant analysis revealed significant differences post-spirometry (vs. baseline 66.7% cross validated accuracy [CVA], p < 0.05) and exercise (vs. baseline 70.4% CVA, p < 0.05). E-nose measurements in healthy individuals are consistent, unaffected by spirometry or physical exercise. However, in asthma patients, significant changes in exhaled VOCs were detected post-activities, indicating airway responses likely due to constriction or inflammation, underscoring the e-nose's potential for respiratory condition diagnosis and monitoring.
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页数:6
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