An Opto-electrophysiology Neural Probe with Photoelectric Artifact-Free for Advanced Single-Neuron Analysis

被引:2
作者
Xu, Qingda [1 ,2 ]
Xi, Ye [1 ,2 ]
Wang, Longchun [1 ]
Du, Zhiyuan [1 ,2 ]
Xu, Mengfei [1 ,2 ]
Ruan, Tao [1 ,2 ]
Cao, Jiawei [1 ,2 ]
Zheng, Kunyu [1 ,2 ]
Wang, Xiaolin [1 ]
Yang, Bin [1 ]
Liu, Jingquan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Natl Key Lab Adv Micro & Nano Manufacture Technol, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, DCI Joint Team, Collaborat Innovat Ctr IFSA, Dept Micro Nano Elect, Shanghai 200240, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
optoelectrical integration; neural probe; photoelectricalartifact; glass tube; intracellular sensing; NANOELECTRODES; RECORDINGS;
D O I
10.1021/acsnano.4c07379
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Opto-electrophysiology neural probes targeting single-cell levels offer an important avenue for elucidating the intrinsic mechanisms of the nervous system using different physical quantities, representing a significant future direction for brain-computer interface (BCI) devices. However, the highly integrated structure poses significant challenges to fabrication processes and the presence of photoelectric artifacts complicates the extraction and analysis of target signals. Here, we propose a highly miniaturized and integrated opto-electrophysiology neural probe for electrical recording and optical stimulation at the single-cell/subcellular level. The design of a total internal reflection layer addresses the photoelectric artifacts that are more pronounced in single-cell devices compared to conventional implantable BCI devices. Finite element simulations and electrical signal tests demonstrate that the opto-electrophysiology neural probe eliminates the photoelectric artifacts in the time domain, which represents a significant breakthrough for optoelectrical integrated BCI devices. Our proposed opto-electrophysiology neural probe holds substantial potential for promoting the development of in vivo BCI devices and developing advanced therapeutic strategies for neurological disorders.
引用
收藏
页码:25193 / 25204
页数:12
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