SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient

被引：0

作者：

Mendes-Correa, Maria Cassia ^{[1
]}

Ghilardi, Fabio de Rose ^{[2
]}

Salomao, Matias Chiarastelli ^{[3
,4
]}

Villas-Boas, Lucy Santos ^{[1
]}

Paula, Anderson Vicente de

Paiao, Heuder Gustavo Oliveira ^{[1
]}

Costa, Antonio Charlys da

Tozetto-Mendoza, Tania Regina ^{[1
]}

Freire, Wilton ^{[1
]}

Sales, Flavia Cristina Silva ^{[2
]}

Claro, Ingra Morales ^{[1
,2
]}

Sabino, Ester Cerdeira ^{[2
]}

Faria, Nuno Rodrigues ^{[2
,5
,6
]}

Witkin, Steven Sol ^{[1
,7
]}

机构：

[1] Univ Sao Paulo, Fac Med, Inst Med Trop Sao Paulo LIM 52, Av Dr Eneas Carvalho Aguiar 470, BR-05403000 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Fac Med, Inst Med Trop Sao Paulo LIM 46, Sao Paulo, SP, Brazil

[3] Hosp 9 Julho, Sao Paulo, SP, Brazil

[4] Univ Sao Paulo, Hosp Clin, Fac Med, Sao Paulo, SP, Brazil

[5] Imperial Coll, Dept Infect Dis Epidemiol, London, England

[6] Univ Oxford, Dept Zool, Oxford, England

[7] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY USA

来源：

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2024年 / 66卷

基金：

巴西圣保罗研究基金会; 英国医学研究理事会;

关键词：

SARS-CoV-2; Cell culture; Evolution; Immunodeficiency; Shedding;

D O I：

10.1590/S1678-9946202466028

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40 -year -old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B -cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication -positive virus that had undergone genetic variation for at least 196 days after symptom onset.

引用

页数：7

共 20 条

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