Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation

被引:16
|
作者
Theoharides, Theoharis C. [1 ,2 ,3 ]
Twahir, Assma [1 ]
Kempuraj, Duraisamy [1 ]
机构
[1] Nova Southeastern Univ, Dr Kiran C Patel Coll Osteopath Med, Inst Neuroimmune Med, Ft Lauderdale, FL USA
[2] Tufts Univ, Sch Med, Dept Immunol, Lab Mol Immunopharmacol & Drug Discovery, Boston, MA USA
[3] Nova Southeastern Univ, Inst Neuro Immune Med, 3400 Gulf Bay Blvd,Room 3748, Clearwater, FL 33759 USA
关键词
AUTISM SPECTRUM DISORDERS; CHRONIC-FATIGUE-SYNDROME; CORTICOTROPIN-RELEASING HORMONE; BLOOD-BRAIN-BARRIER; POSTURAL TACHYCARDIA SYNDROME; PITUITARY-ADRENOCORTICAL AXIS; MTOR SIGNALING PATHWAY; SUBSTANCE-P; SYNDROME/MYALGIC ENCEPHALOMYELITIS; HISTAMINE-SECRETION;
D O I
10.1016/j.anai.2023.10.032
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Mast cells (MC) are ubiquitous in the body, and they are critical for not only in allergic diseases but also in immunity and in flammation, including having potential involvement in the pathophysiology of dysautonomias and neuroin flammatory disorders. MC are located perivascularly close to nerve endings and sites such as the carotid bodies, heart, hypothalamus, the pineal gland, and the adrenal gland that would allow them not only to regulate but also to be affected by the autonomic nervous system (ANS). MC are stimulated not only by allergens but also many other triggers including some from the ANS that can affect MC release of neurosensitizing, proin flamma- tory, and vasoactive mediators. Hence, MC may be able to regulate homeostatic functions that seem to be dysfunctional in many conditions, such as postural orthostatic tachycardia syndrome, autism spectrum disorder, myalgic encephalomyelitis/chronic fatigue syndrome, and Long-COVID syndrome. The evidence indicates that there is a possible association between these conditions and diseases associated with MC activation. There is no effective treatment for any form of these conditions other than minimizing symptoms. Given the many ways MC could be activated and the numerous mediators released, it would be important to develop ways to inhibit stimulation of MC and the release of ANS -relevant mediators. (c) 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:440 / 454
页数:15
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