central nervous system;
tuberculoma;
scrub typhus;
MENINGITIS;
MENINGOENCEPHALITIS;
D O I:
10.3892/etm.2024.12548
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Central nervous system (CNS) tuberculosis mainly manifests as tuberculous meningitis and intracranial tuberculosis; intramedullary tuberculosis is uncommon. Scrub typhus is an acute naturally occurring infectious disease caused by Orientia tsutsugamushi. CNS tuberculoma following typhus is rare. The present study described a 60-year-old man with high fever, muscle soreness, yellowish skin and sclera and hepatosplenomegaly. At first, the patient was diagnosed with scrub typhus, after treatment with doxycycline he recovered completely. However, half a month after discharge, the patient experienced headache, night sweats and anorexia. Tuberculosis-specific enzyme-linked immunospot assay showed positive Mycobacterium tuberculosis antibody in cerebrospinal fluid (CSF). Metagenomic next-generation sequencing detected the presence of Mycobacterium tuberculosis in CSF. Magnetic resonance imaging of the brain and spinal cord showed multiple rings enhancing lesions in the cerebral hemispheres, cerebellum, brainstem and spinal cords. After the diagnosis of CNS tuberculoma, the patient was started on conventional anti-tuberculosis therapy resulting in a good prognosis.
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Ono, Yuko
Ikegami, Yukihiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Ikegami, Yukihiro
Tasaki, Kazuhiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Pathol, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Tasaki, Kazuhiro
Abe, Masahumi
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Pathol, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Abe, Masahumi
Tase, Choichiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Zandvakili, Arya
Kobayashi, Takaaki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Kobayashi, Takaaki
Kaewpoowat, Quanhathai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Kaewpoowat, Quanhathai
Parsons, Meredith G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Parsons, Meredith G.
Ford, Bradley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Ford, Bradley
Barker, Jason H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bolla, Tukaram
Bhattarai, Sushmita
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bhattarai, Sushmita
Singh, Harpreet
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Singh, Harpreet
Suri, Vikas
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Suri, Vikas
Bhalla, Ashish
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bhalla, Ashish
Chatterjee, Debajyoti
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Histopathol, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Ono, Yuko
Ikegami, Yukihiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Ikegami, Yukihiro
Tasaki, Kazuhiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Pathol, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Tasaki, Kazuhiro
Abe, Masahumi
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Pathol, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
Abe, Masahumi
Tase, Choichiro
论文数: 0引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, JapanFukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima 9601295, Japan
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Zandvakili, Arya
Kobayashi, Takaaki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Kobayashi, Takaaki
Kaewpoowat, Quanhathai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Kaewpoowat, Quanhathai
Parsons, Meredith G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Parsons, Meredith G.
Ford, Bradley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
Ford, Bradley
Barker, Jason H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USAUniv Iowa Hosp & Clin, Dept Internal Med, Div Gen Internal Med, Iowa City, IA 52242 USA
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bolla, Tukaram
Bhattarai, Sushmita
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bhattarai, Sushmita
Singh, Harpreet
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Singh, Harpreet
Suri, Vikas
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Suri, Vikas
Bhalla, Ashish
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India
Bhalla, Ashish
Chatterjee, Debajyoti
论文数: 0引用数: 0
h-index: 0
机构:
Post Grad Inst Med Educ & Res, Dept Histopathol, Chandigarh 160012, IndiaPost Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India