The evolution, complexity, and diversity of swine influenza viruses in China: A hidden public health threat

被引：0
作者：
Cai, Mengkai [1 ]
Wei, Zhi [2 ,3 ,4 ]
Hu, Xiaokun
Ji, Yikuan [1 ]
Li, Shaofang [1 ]
Huang, Junmei [1 ]
Jin, Rong [1 ]
Liang, Quanming [1 ]
Zhang, Guihong [2 ,3 ,4 ]
Zheng, Zezhong [2 ,3 ,4 ]
Gong, Lang [2 ,3 ,4 ,5 ]
Li, Meidi [1 ]
机构：
[1] Guangdong Meizhou Vocat & Tech Coll, Meizhou Engn Res Ctr Vet Med & Nat Med, Meizhou 514028, Peoples R China
[2] South China Agr Univ, Coll Vet Med, Guangdong Prov Key Lab Zoonosis Prevent & Control, Guangzhou 510462, Peoples R China
[3] Maoming Branch, Guangdong Lab Lingnan Modern Agr, Maoming 525000, Peoples R China
[4] Minist Agr & Rural Affairs, Key Lab Anim Vaccine Dev, Guangzhou 510462, Peoples R China
[5] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
来源：
VIROLOGY | 2024年 / 598卷
关键词：
Swine influenza virus; Evolution; Pathogenicity; AMINO-ACID SUBSTITUTION; GENETIC-CHARACTERIZATION; TRANSMISSION DYNAMICS; POLYMERASE-ACTIVITY; 2009; H1N1; PIGS; VIRULENCE; PATHOGENICITY; MUTATIONS; GENOTYPE;
D O I：
10.1016/j.virol.2024.110167
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Swine influenza viruses (SIVs), including H1N1, H1N2, and H3N2, have spread throughout the global pig population. Potential pandemics are a concern with the recent sporadic cross-species transmission of SIVs to humans. We collected 1421 samples from Guangdong, Fujian, Henan, Yunnan and Jiangxi provinces during 2017-2018 and isolated 29 viruses. These included 21H1N1, 5H1N2, and 3H3N2 strains. Genome analysis showed that the domestic epidemic genotypes of H1N1 were mainly G4 and G5 reassortant EA swine H1N1. These genotypes have a clear epidemic advantage. Two strains were Clade 6B.1 pdm/09H1N1, suggesting a possible pig-to-human transmission route. Notably, three new H1N2 genotypes were identified using the genomic backbones of G4 or G5 viruses for recombination. The identification of various subtypes and genotypes highlight the complexity and diversity of SIVs in China and need for continuous monitoring of SIV evolution to assess the risks and prepare for potential influenza pandemics.
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