Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila

被引：1

作者：

Diamandi, Julia A. ^{[1
]}

Duckhorn, Julia C. ^{[1
]}

Miller, Kara E. ^{[1
]}

Weinstock, Mason ^{[1
]}

Leone, Sofia ^{[1
]}

Murphy, Micaela R. ^{[1
]}

Shirangi, Troy R. ^{[1
]}

机构：

[1] Villanova Univ, Dept Biol, 800 East Lancaster Ave, Villanova, PA 19085 USA

来源：

CURRENT BIOLOGY | 2024年 / 34卷 / 06期

基金：

美国国家科学基金会;

关键词：

CENTRAL-NERVOUS-SYSTEM; DOUBLESEX GENE; BRAIN; DIFFERENTIATION; METAMORPHOSIS; EXPRESSION;

D O I：

10.1016/j.cub.2024.01.065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most larval neurons in Drosophila are repurposed during metamorphosis for functions in adult life, but their contribution to the neural circuits for sexually dimorphic behaviors is unknown. Here, we identify two interneurons in the nerve cord of adult Drosophila females that control ovipositor extrusion, a courtship rejection behavior performed by mated females. We show that these two neurons are present in the nerve cord of larvae as mature, sexually monomorphic interneurons. During pupal development, they acquire the expression of the sexual differentiation gene, doublesex ; undergo doublesex -dependent programmed cell death in males; and are remodeled in females for functions in female mating behavior. Our results demonstrate that the neural circuits for courtship in Drosophila are built in part using neurons that are sexually reprogrammed from former sex -shared activities in larval life.

引用

页码：1183 / 1193.e3

页数：15

共 34 条

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