Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila

被引：1
作者：
Diamandi, Julia A. [1 ]
Duckhorn, Julia C. [1 ]
Miller, Kara E. [1 ]
Weinstock, Mason [1 ]
Leone, Sofia [1 ]
Murphy, Micaela R. [1 ]
Shirangi, Troy R. [1 ]
机构：
[1] Villanova Univ, Dept Biol, 800 East Lancaster Ave, Villanova, PA 19085 USA
来源：
CURRENT BIOLOGY | 2024年 / 34卷 / 06期
基金：
美国国家科学基金会;
关键词：
CENTRAL-NERVOUS-SYSTEM; DOUBLESEX GENE; BRAIN; DIFFERENTIATION; METAMORPHOSIS; EXPRESSION;
D O I：
10.1016/j.cub.2024.01.065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Most larval neurons in Drosophila are repurposed during metamorphosis for functions in adult life, but their contribution to the neural circuits for sexually dimorphic behaviors is unknown. Here, we identify two interneurons in the nerve cord of adult Drosophila females that control ovipositor extrusion, a courtship rejection behavior performed by mated females. We show that these two neurons are present in the nerve cord of larvae as mature, sexually monomorphic interneurons. During pupal development, they acquire the expression of the sexual differentiation gene, doublesex ; undergo doublesex -dependent programmed cell death in males; and are remodeled in females for functions in female mating behavior. Our results demonstrate that the neural circuits for courtship in Drosophila are built in part using neurons that are sexually reprogrammed from former sex -shared activities in larval life.
引用
收藏
页码：1183 / 1193.e3
页数：15
相关论文
共 34 条
  • [1] Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions
    Ahmed, Eman I.
    Zehr, Julia L.
    Schulz, Kalynn M.
    Lorenz, Betty H.
    DonCarlos, Lydia L.
    Sisk, Cheryl L.
    [J]. NATURE NEUROSCIENCE, 2008, 11 (09) : 995 - 997
  • [2] Altered electrical properties in Drosophila neurons developing without synaptic transmission
    Baines, RA
    Uhler, JP
    Thompson, A
    Sweeney, ST
    Bate, M
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (05) : 1523 - 1531
  • [3] Neuroblast pattern and identity in the Drosophila tail region and role of doublesex in the survival of sex-specific precursors
    Birkholz, Oliver
    Rickert, Christof
    Berger, Christian
    Urbach, Rolf
    Technau, Gerhard M.
    [J]. DEVELOPMENT, 2013, 140 (08): : 1830 - 1842
  • [4] DROSOPHILA DOUBLESEX GENE CONTROLS SOMATIC SEXUAL-DIFFERENTIATION BY PRODUCING ALTERNATIVELY SPLICED MESSENGER-RNAS ENCODING RELATED SEX-SPECIFIC POLYPEPTIDES
    BURTIS, KC
    BAKER, BS
    [J]. CELL, 1989, 56 (06) : 997 - 1010
  • [5] Sexual Dimorphism in the Fly Brain
    Cachero, Sebastian
    Ostrovsky, Aaron D.
    Yu, Jai Y.
    Dickson, Barry J.
    Jefferis, Gregory S. X. E.
    [J]. CURRENT BIOLOGY, 2010, 20 (18) : 1589 - 1601
  • [6] MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
    Carreira-Rosario, Arnaldo
    Zarin, Aref Arzan
    Clark, Matthew Q.
    Manning, Laurina
    Fetter, Richard D.
    Cardona, Albert
    Doe, Chris Q.
    [J]. ELIFE, 2018, 7
  • [7] Dendritic remodeling and growth of motoneurons during metamorphosis of Drosophila melanogaster
    Consoulas, C
    Restifo, LL
    Levine, RB
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (12) : 4906 - 4917
  • [8] Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction
    Duckhorn, Julia C.
    Cande, Jessica
    Metkus, Mary C.
    Song, Hyeop
    Altamirano, Sofia
    Stern, David L.
    Shirangi, Troy R.
    [J]. CURRENT BIOLOGY, 2022, 32 (08) : 1703 - +
  • [9] Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system
    Harris, Robin M.
    Pfeiffer, Barret D.
    Rubin, Gerald M.
    Truman, James W.
    [J]. ELIFE, 2015, 4
  • [10] Klapoetke NC, 2014, NAT METHODS, V11, P338, DOI [10.1038/nmeth.2836, 10.1038/NMETH.2836]
1234