SARS-CoV-2 infections in patients enrolled on the Children's Oncology Group standard-risk B-cell acute lymphoblastic leukemia trial, AALL1731

被引：2

作者：

Elgarten, Caitlin W. ^{[1
]}

Kairalla, John A. ^{[2
]}

Thompson, Joel C. ^{[3
]}

Miller, Tamara P. ^{[4
]}

Wang, Cindy ^{[2
]}

Conway, Susan ^{[2
]}

Loh, Mignon L. ^{[5
,6
]}

Raetz, Elizabeth A. ^{[7
]}

Gupta, Sumit ^{[8
]}

Rau, Rachel E. ^{[9
]}

Angiolillo, Anne ^{[10
]}

Rabin, Karen R. ^{[9
]}

Alexander, Sarah ^{[8
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Div Oncol, Philadelphia, PA USA

[2] Univ Florida, Dept Biostat, Gainesville, FL USA

[3] Univ Missouri Kansas City, Childrens Mercy Hosp, Dept Pediat, Div Hematol Oncol Bone Marrow Transplant, Kansas City, MO USA

[4] Childrens Healthcare Atlanta Egleston, Pediat Hematol Oncol, Atlanta, GA USA

[5] Univ Washington, Seattle Childrens Res Inst, Ben Towne Ctr Childhood Canc Res, Seattle, WA USA

[6] Univ Washington, Seattle Childrens Hosp, Dept Pediat, Seattle, WA USA

[7] NYU Langone, Laura & Isaac Perlmutter Canc Ctr, New York, NY USA

[8] Hosp Sick Children, Div Hematol Oncol, Toronto, ON, Canada

[9] Baylor Coll Med, Pediat Hematol Oncol, Houston, TX USA

[10] Childrens Natl Med Ctr, Ctr Canc & Blood Disorders, Washington, DC USA

来源：

EJHAEM | 2023年 / 4卷 / 03期

关键词：

B-ALL; pediatrics; SARS-CoV-2; ADOLESCENTS; COVID-19; OUTCOMES; CANCER;

D O I：

10.1002/jha2.697

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematologic malignancy is a risk factor for severe coronavirus disease 2019 (COVID-19) in adults; however, data specific to children with leukemia are limited. High-quality infectious adverse event data from the ongoing Children's Oncology Group (COG) standard-risk B acute lymphoblastic leukemia/lymphoma (ALL/LLy) trial, AALL1731, were analyzed to provide a disease-specific estimate of SARS-CoV-2 infection outcomes in pediatric ALL. Of 253 patients with reported infections, the majority (77.1%) were asymptomatic or mildly symptomatic (CTCAE grade 1/2) and there was a single COVID-19-related death. These data suggest SARS-CoV-2 infection does not confer substantial morbidity among young patients with B-lymphoblastic leukemia/lymphoma (B-ALL/LLy).

引用

页码：745 / 750

页数：6

共 17 条

[1] COVID-19 in pediatric oncology from French pediatric oncology and hematology centers: High risk of severe forms? [J].

Andre, Nicolas ;

Rouger-Gaudichon, Jeremie ;

Brethon, Benoit ;

Phulpin, Aurelie ;

Thebault, Eric ;

Pertuisel, Sophie ;

Gandemer, Virginie .

PEDIATRIC BLOOD & CANCER, 2020, 67 (07)

[2] COVID-19 in Children With Cancer in New York City [J].

Boulad, Farid ;

Kamboj, Mini ;

Bouvier, Nancy ;

Mauguen, Audrey ;

Kung, Andrew L. .

JAMA ONCOLOGY, 2020, 6 (09) :1459-1460

[3] Improving infectious adverse event reporting for children and adolescents enrolled in clinical trials for acute lymphoblastic leukemia: A report from the Children's Oncology Group [J].

Elgarten, Caitlin W. ;

Thompson, Joel C. ;

Angiolillo, Anne ;

Chen, Zhiguo ;

Conway, Susan ;

Devidas, Meenakshi ;

Gupta, Sumit ;

Kairalla, John A. ;

McNeer, Jennifer L. ;

O'Brien, Maureen M. ;

Rabin, Karen R. ;

Rau, Rachel E. ;

Rheingold, Susan R. ;

Wang, Cindy ;

Wood, Charlotte ;

Raetz, Elizabeth A. ;

Loh, Mignon L. ;

Alexander, Sarah ;

Miller, Tamara P. .

PEDIATRIC BLOOD & CANCER, 2022, 69 (11)

[4] COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey [J].

Emes, David ;

Huls, Anke ;

Baumer, Nicole ;

Dierssen, Mara ;

Puri, Shiela ;

Russell, Lauren ;

Sherman, Stephanie L. ;

Strydom, Andre ;

Bargagna, Stefania ;

Brandao, Ana Claudia ;

Costa, Alberto C. S. ;

Feany, Patrick T. ;

Chicoine, Brian Allen ;

Ghosh, Sujay ;

Rebillat, Anne-Sophie ;

Sgandurra, Giuseppina ;

Valentini, Diletta ;

Rohrer, Tilman R. ;

Levin, Johannes ;

Lakhanpaul, Monica .

JOURNAL OF CLINICAL MEDICINE, 2021, 10 (21)

[5] Assessment of enrollment characteristics for Children's Oncology Group (COG) upfront therapeutic clinical trials 2004-2015 [J].

Faulk, Kelly E. ;

Anderson-Mellies, Amy ;

Cockburn, Myles ;

Green, Adam L. .

PLOS ONE, 2020, 15 (04)

[6] COVID-19 in persons with haematological cancers [J].

He, Wenjuan ;

Chen, Lei ;

Chen, Li ;

Yuan, Guolin ;

Fang, Yun ;

Chen, Wenlan ;

Wu, Di ;

Liang, Bo ;

Lu, Xiaoting ;

Ma, Yanling ;

Li, Lei ;

Wang, Hongxiang ;

Chen, Zhichao ;

Li, Qiubai ;

Gale, Robert Peter .

LEUKEMIA, 2020, 34 (06) :1637-1645

[7] SARS-CoV-2 in Childhood Cancer in 2020: A Disease of Disparities [J].

Johnston, Emily E. ;

Martinez, Isaac ;

Davis, Elizabeth S. ;

Caudill, Caroline ;

Richman, Joshua ;

Brackett, Julienne ;

Dickens, David S. ;

Kahn, Alissa ;

Schwalm, Carla ;

Sharma, Archana ;

Patel, Pratik A. ;

Bhatia, Smita ;

Levine, Jennifer M. ;

Wolfson, Julie A. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (34) :3778-+

[8]

Loh M., 2021, COVID-19 and pediatric ALL: frequently asked questions

[9] Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience [J].

Madhusoodhan, P. Pallavi ;

Pierro, Joanna ;

Musante, Jordan ;

Kothari, Prachi ;

Gampel, Bradley ;

Appel, Burton ;

Levy, Adam ;

Tal, Adit ;

Hogan, Laura ;

Sharma, Archana ;

Feinberg, Shari ;

Kahn, Alissa ;

Pinchinat, Ashley ;

Bhatla, Teena ;

Glasser, Chana L. ;

Satwani, Prakash ;

Raetz, Elizabeth A. ;

Onel, Kenan ;

Carroll, William L. .

PEDIATRIC BLOOD & CANCER, 2021, 68 (03)

[10] Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study [J].

Mukkada, Sheena ;

Bhakta, Nickhill ;

Chantada, Guillermo L. ;

Chen, Yichen ;

Vedaraju, Yuvanesh ;

Faughnan, Lane ;

Homsi, Maysam R. ;

Muniz-Talavera, Hilmarie ;

Ranadive, Radhikesh ;

Metzger, Monika ;

Friedrich, Paola ;

Agulnik, Asya ;

Jeha, Sima ;

Lam, Catherine ;

Dalvi, Rashmi ;

Hessissen, Laila ;

Moreira, Daniel C. ;

Santana, Victor M. ;

Sullivan, Michael ;

Bouffet, Eric ;

Caniza, Miguela A. ;

Devidas, Meenakshi ;

Pritchard-Jones, Kathy ;

Rodriguez-Galindo, Carlos .

LANCET ONCOLOGY, 2021, 22 (10) :1416-1426

← 1 2 →