Case Report: Approaches for managing resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplantation recipients

被引：0
作者：
Song, Eunkyung [1 ,2 ]
机构：
[1] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA
[2] Nationwide Childrens Hosp, Div Infect Dis & Host Def, Columbus, OH 43205 USA
来源：
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词：
pediatric haplo-HCT; resistant cytomegalovirus; maribavir; viral-specific T cell therapy; CMV cell-mediated immunity; LETERMOVIR PROPHYLAXIS; ANTIVIRAL THERAPY; AMERICAN SOCIETY; VIRAL LOAD; INFECTION; DISEASE; MORTALITY; GANCICLOVIR; CHILDREN; ASSAY;
D O I：
10.3389/fped.2024.1394006
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The instructional case is a pediatric haploidentical TCR alpha beta+/CD19+ depleted allogeneic hematopoietic cell transplantation recipient who developed early onset CMV infection, which was complicated by resistant CMV (both UL97 and UL54) and successfully managed with maribavir and haploidentical CMV-specific T lymphocytes. Novel approaches to resistant CMV infection are reviewed and effective utilization of recent advances in diagnosis and management of resistant CMV in pediatric HCT are highlighted.
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页数：8
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