Case Report: Approaches for managing resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplantation recipients

被引：0

作者：

Song, Eunkyung ^{[1
,2
]}

机构：

[1] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA

[2] Nationwide Childrens Hosp, Div Infect Dis & Host Def, Columbus, OH 43205 USA

来源：

FRONTIERS IN PEDIATRICS | 2024年 / 12卷

关键词：

pediatric haplo-HCT; resistant cytomegalovirus; maribavir; viral-specific T cell therapy; CMV cell-mediated immunity; LETERMOVIR PROPHYLAXIS; ANTIVIRAL THERAPY; AMERICAN SOCIETY; VIRAL LOAD; INFECTION; DISEASE; MORTALITY; GANCICLOVIR; CHILDREN; ASSAY;

D O I：

10.3389/fped.2024.1394006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The instructional case is a pediatric haploidentical TCR alpha beta+/CD19+ depleted allogeneic hematopoietic cell transplantation recipient who developed early onset CMV infection, which was complicated by resistant CMV (both UL97 and UL54) and successfully managed with maribavir and haploidentical CMV-specific T lymphocytes. Novel approaches to resistant CMV infection are reviewed and effective utilization of recent advances in diagnosis and management of resistant CMV in pediatric HCT are highlighted.

引用

页数：8