Case Report: Approaches for managing resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplantation recipients

被引：0
作者：
Song, Eunkyung [1 ,2 ]
机构：
[1] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA
[2] Nationwide Childrens Hosp, Div Infect Dis & Host Def, Columbus, OH 43205 USA
来源：
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词：
pediatric haplo-HCT; resistant cytomegalovirus; maribavir; viral-specific T cell therapy; CMV cell-mediated immunity; LETERMOVIR PROPHYLAXIS; ANTIVIRAL THERAPY; AMERICAN SOCIETY; VIRAL LOAD; INFECTION; DISEASE; MORTALITY; GANCICLOVIR; CHILDREN; ASSAY;
D O I：
10.3389/fped.2024.1394006
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The instructional case is a pediatric haploidentical TCR alpha beta+/CD19+ depleted allogeneic hematopoietic cell transplantation recipient who developed early onset CMV infection, which was complicated by resistant CMV (both UL97 and UL54) and successfully managed with maribavir and haploidentical CMV-specific T lymphocytes. Novel approaches to resistant CMV infection are reviewed and effective utilization of recent advances in diagnosis and management of resistant CMV in pediatric HCT are highlighted.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Cytomegalovirus viral load at initiation of pre-emptive antiviral therapy impacts cytomegalovirus dynamics in pediatric allogeneic hematopoietic cell transplantation recipients
    Gutierrez, Valentina
    Stanek, Joseph
    Ardura, Monica I.
    Song, Eunkyung
    TRANSPLANT INFECTIOUS DISEASE, 2024, 26 (06)
  • [2] A Mortality Analysis of Letermovir Prophylaxis for Cytomegalovirus (CMV) in CMV-seropositive Recipients of Allogeneic Hematopoietic Cell Transplantation
    Ljungman, Per
    Schmitt, Michael
    Marty, Francisco M.
    Maertens, Johan
    Chemaly, Roy F.
    Kartsonis, Nicholas A.
    Butterton, Joan R.
    Wan, Hong
    Teal, Valerie L.
    Sarratt, Kendra
    Murata, Yoshihiko
    Leavitt, Randi Y.
    Badshah, Cyrus
    CLINICAL INFECTIOUS DISEASES, 2020, 70 (08) : 1525 - 1533
  • [3] Study of cytomegalovirus resistance in allogeneic hematopoietic cell transplant recipients
    Guiu, Alba
    Lopez-Aladid, Ruben
    Cardenoso, Laura
    Mar Mosquera, Maria
    de la Camara, Rafael
    Angeles Marcos, Maria
    MEDICINA CLINICA, 2020, 154 (11): : 433 - 439
  • [4] Cost analysis of ganciclovir and foscarnet in recipients of allogeneic hematopoietic cell transplant with cytomegalovirus viremia
    Chen, Jason
    Ross, Justine Abella
    Tegtmeier, Bernard
    Yang, Dongyun
    Ito, James I.
    Zaia, John A.
    Dickter, Jana K.
    Nakamura, Ryotaro
    Mokhtari, Sally
    Kriengkauykiat, Jane
    Al Malki, Monzr M.
    Dadwal, Sanjeet S.
    TRANSPLANT INFECTIOUS DISEASE, 2020, 22 (02)
  • [5] High dose valacyclovir for cytomegalovirus prophylaxis following allogeneic hematopoietic cell transplantation
    Hawks, Kelly G.
    Fegley, Amanda
    Sabo, Roy T.
    Roberts, Catherine H.
    Toor, Amir A.
    JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2023, 29 (01) : 130 - 137
  • [6] Letermovir for Prevention of Recurrent Cytomegalovirus in High-Risk Allogeneic Hematopoietic Cell Transplantation Recipients
    Han, Gyuri
    Stern, Anat
    Lee, Yeon Joo
    Li, Yuxuan
    Dahi, Parastoo B.
    Tamari, Roni
    Gyurkocza, Boglarka
    Jakubowski, Ann A.
    Papadopoulos, Esperanza B.
    Shaffer, Brian
    Perales, Miguel-Angel
    Obeid, Karam M.
    Young, Jo-Anne H.
    Papanicolaou, Genovefa A.
    TRANSPLANTATION AND CELLULAR THERAPY, 2025, 31 (02): : 105.e1 - 105.e9
  • [7] Update on Cytomegalovirus Infection Management in Allogeneic Hematopoietic Stem Cell Transplant Recipients. A Consensus Document of the Spanish Group for Hematopoietic Transplantation and Cell Therapy (GETH-TC)
    Pinana, Jose Luis
    Gimenez, Estela
    Vazquez, Lourdes
    Marcos, Maria Angeles
    Guerreiro, Manuel
    Duarte, Rafael
    Perez, Ariadna
    de Miguel, Carlos
    Espigado, Ildefonso
    Gonzalez-Vicent, Marta
    Suarez-Lledo, Maria
    Garcia-Cadenas, Irene
    Martino, Rodrigo
    Cedillo, Angel
    Rovira, Monserrat
    de la Camara, Rafael
    Navarro, David
    Solano, Carlos
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2024, 16 (01)
  • [8] Clinical Usefulness of Monitoring Cytomegalovirus-Specific Immunity by Quantiferon-CMV in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients
    Lee, Sae-Mi
    Kim, Yae-Jean
    Yoo, Keon Hee
    Sung, Ki Woong
    Koo, Hong Hoe
    Kang, Eun-Suk
    ANNALS OF LABORATORY MEDICINE, 2017, 37 (03) : 277 - 281
  • [9] Low-Level Cytomegalovirus Antigenemia Promotes Protective Cytomegalovirus Antigen-Specific T Cells after Allogeneic Hematopoietic Cell Transplantation
    Chen, George L.
    Wallace, Paul K.
    Zhang, Yali
    Tario, Joseph D.
    Przespolewski, Amanda C.
    Becker, Joanne
    Almyroudis, Nikolaos G.
    Ross, Maureen
    Riches, Marcie
    Segal, Brahm H.
    Brix, Liselotte
    McCarthy, Philip L.
    Hahn, Theresa
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (11) : 2147 - 2154
  • [10] Effectiveness of letermovir for cytomegalovirus prophylaxis in allogeneic hematopoietic stem cell transplant recipients: A global systematic review
    Sepassi, Aryana
    Saunders, Ila M.
    Bounthavong, Mark
    Taplitz, Randy A.
    Logan, Cathy
    Watanabe, Jonathan H.
    JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION, 2023, 63 (04) : 1138 - 1149
12345