Advanced polymer composites and polymer hybrids for cartilage tissue engineering

被引：2
作者：
Liu, Shan [1 ]
Hu, Xiao [2 ]
He, Min [3 ]
Liu, Wei [1 ]
Zhou, Dengfeng [1 ]
Li, Yang [1 ]
Qin, Shuhao [3 ]
机构：
[1] Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China
[2] Guizhou Prov Peoples Hosp, Dept Neurol, Guiyang, Peoples R China
[3] Guizhou Univ, Coll Mat & Met, Guiyang 550025, Peoples R China
来源：
POLYMER COMPOSITES | 2024年 / 45卷 / 13期
基金：
中国国家自然科学基金;
关键词：
biolubricant; cartilage; drug delivery; polymer scaffold; sustained release; tissue engineering; ENHANCED CHONDROGENIC DIFFERENTIATION; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEM; IN-VITRO; ELECTROSPUN SCAFFOLDS; MECHANICAL-PROPERTIES; NANOFIBROUS SCAFFOLD; REPAIR; BONE; REGENERATION;
D O I：
10.1002/pc.28646
中图分类号：
TB33 [复合材料];
学科分类号：
摘要：
The repair and regeneration of cartilage is a challenge for scientists and clinical surgery. Achieving cell adhesion and regeneration, anti-inflammatory, lubrication, targeted drug delivery and controlled release simultaneously in cartilage treatment are the goals of researchers. Polymer composites and hybrids have the potential to realize above functions in cartilage tissue engineering. This review refers to cartilage injuries, current clinical techniques, and their benefits and limitations, focusing on the most relevant and state of art of advanced polymers for cartilage tissue engineering. The frontier applications of multifunctional polymer composites and hybrids in cartilage tissue engineering are discussed in depth, including polymer scaffold, polymer bio-lubricant, and zwitterionic polymer for drug delivery and sustained drug release. A summary of comprehensive properties of polymers such as processability, mechanical properties, biocompatibility, biodegradability, hydrophilicity, cytotoxicity, etc., and their mechanisms are analyzed. Furthermore, some key challenges and outstanding concerns on polymer-based materials for cartilage tissue engineering are presented followed by future perspectives.
引用
收藏
页码：11560 / 11590
页数：31
相关论文
共 199 条
[71]   Articular cartilage inspired bilayer coating on Ti6Al4V alloy with low friction and high load-bearing properties [J].
Li, Aosong ;
Su, Fenghua ;
Chu, Paul K. ;
Sun, Jianfang .
APPLIED SURFACE SCIENCE, 2020, 515
[72]   Recent advances of PVA-based hydrogels in cartilage repair application [J].
Li, Heng ;
Wu, Chengwei ;
Yu, Xiaogang ;
Zhang, Wei .
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 2023, 24 :2279-2298
[73]   Biomimetic Injectable Hydrogel Based on Methacrylate-Modified Silk Fibroin Embedded with Kartogenin for Superficial Cartilage Regeneration [J].
Li, Huimin ;
Tong, Zhicheng ;
Fang, Yifei ;
Liu, Fengling ;
He, Feng ;
Teng, Chong .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 10 (01) :507-514
[74]   Lithium Chloride-Releasing 3D Printed Scaffold for Enhanced Cartilage Regeneration [J].
Li, Jiayi ;
Yao, Qingqiang ;
Xu, Yan ;
Zhang, Huikang ;
Li, Liang-liang ;
Wang, Liming .
MEDICAL SCIENCE MONITOR, 2019, 25 :4041-4050
[75]   Preparation of HAp whiskers with or without Mg ions and their effects on the mechanical properties and osteogenic activity of poly(D,L-lactide) [J].
Li, Wenyan ;
Lu, Yaoting ;
Liu, Kun ;
Wen, Wei ;
Liu, Mingxian ;
Li, Hong ;
Zhou, Changren ;
Luo, Binghong .
COMPOSITES PART B-ENGINEERING, 2020, 196 (196)
[76]   Graphene Oxide-loaded magnetic nanoparticles within 3D hydrogel form High-performance scaffolds for bone regeneration and tumour treatment [J].
Li, Yan ;
Huang, Lijing ;
Tai, Guangpin ;
Yan, Feifei ;
Cai, Lin ;
Xin, Chenxing ;
Al Islam, Shamoon .
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 2022, 152
[77]   Biodegradable polymers: an update on drug delivery in bone and cartilage diseases [J].
Lima, Ana Claudia ;
Ferreira, Helena ;
Reis, Rui L. ;
Neves, Nuno M. .
EXPERT OPINION ON DRUG DELIVERY, 2019, 16 (08) :795-813
[78]   Nanofibrous Wharton's jelly scaffold in combination with adipose-derived stem cells for cartilage engineering [J].
Lin, Liqin ;
Xu, Yawen ;
Li, Yaqiang ;
Gong, Xiaodi ;
Wei, Min ;
Zhang, Wei ;
Zhang, Xue ;
Xu, Yong .
MATERIALS & DESIGN, 2020, 186
[79]   A bilineage thermosensitive hydrogel system for stimulation of mesenchymal stem cell differentiation and enhancement of osteochondral regeneration [J].
Lin, Tzu-Hsiang ;
Wang, Hsueh-Chun ;
Wu, Meng-Chian ;
Hsu, Horng-Chaung ;
Yeh, Ming-Long .
COMPOSITES PART B-ENGINEERING, 2022, 233
[80]   Single-layer temperature-adjusting transition method to improve the bond strength of 3D-printed PCL/PLA parts [J].
Lin, Weiyi ;
Shen, Hongyao ;
Xu, Guanhua ;
Zhang, Linchu ;
Fu, Jianzhong ;
Deng, Xiaolei .
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 2018, 115 :22-30
3456789101112