Advanced polymer composites and polymer hybrids for cartilage tissue engineering

被引：5
作者：
Liu, Shan [1 ]
Hu, Xiao [2 ]
He, Min [3 ]
Liu, Wei [1 ]
Zhou, Dengfeng [1 ]
Li, Yang [1 ]
Qin, Shuhao [3 ]
机构：
[1] Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China
[2] Guizhou Prov Peoples Hosp, Dept Neurol, Guiyang, Peoples R China
[3] Guizhou Univ, Coll Mat & Met, Guiyang 550025, Peoples R China
来源：
POLYMER COMPOSITES | 2024年 / 45卷 / 13期
基金：
中国国家自然科学基金;
关键词：
biolubricant; cartilage; drug delivery; polymer scaffold; sustained release; tissue engineering; ENHANCED CHONDROGENIC DIFFERENTIATION; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEM; IN-VITRO; ELECTROSPUN SCAFFOLDS; MECHANICAL-PROPERTIES; NANOFIBROUS SCAFFOLD; REPAIR; BONE; REGENERATION;
D O I：
10.1002/pc.28646
中图分类号：
TB33 [复合材料];
学科分类号：
摘要：
The repair and regeneration of cartilage is a challenge for scientists and clinical surgery. Achieving cell adhesion and regeneration, anti-inflammatory, lubrication, targeted drug delivery and controlled release simultaneously in cartilage treatment are the goals of researchers. Polymer composites and hybrids have the potential to realize above functions in cartilage tissue engineering. This review refers to cartilage injuries, current clinical techniques, and their benefits and limitations, focusing on the most relevant and state of art of advanced polymers for cartilage tissue engineering. The frontier applications of multifunctional polymer composites and hybrids in cartilage tissue engineering are discussed in depth, including polymer scaffold, polymer bio-lubricant, and zwitterionic polymer for drug delivery and sustained drug release. A summary of comprehensive properties of polymers such as processability, mechanical properties, biocompatibility, biodegradability, hydrophilicity, cytotoxicity, etc., and their mechanisms are analyzed. Furthermore, some key challenges and outstanding concerns on polymer-based materials for cartilage tissue engineering are presented followed by future perspectives.
引用
收藏
页码：11560 / 11590
页数：31
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