Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations

被引:2
作者
Grover, Monica [1 ]
Ashraf, Ambika P. [2 ]
Bowden, Sasigarn A. [3 ]
Calabria, Andrew [4 ]
Diaz-Thomas, Alicia [5 ]
Krishnan, Sowmya [6 ]
Miller, Jennifer L. [7 ]
Robinson, Marie-Eve [8 ,9 ]
DiMeglio, Linda A. [10 ]
机构
[1] Stanford Sch Med, Dept Pediat, Div Pediat Endocrinol, Stanford, CA 94305 USA
[2] Univ Alabama Birmingham, Dept Pediat, Div Pediat Endocrinol & Diabet, Birmingham, AL USA
[3] Ohio State Univ, Nationwide Childrens Hosp, Dept Pediat, Div Pediat Endocrinol, Columbus, OH USA
[4] Childrens Hosp Philadelphia, Dept Pediat, Div Endocrinol & Diabet, Philadelphia, PA USA
[5] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Div Pediat Endocrinol, Memphis, TN USA
[6] Univ Texas Southwestern Med Ctr, Dept Pediat, Sect Diabet & Endocrinol, Dallas, TX USA
[7] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Div Pediat Endocrinol, Chicago, IL USA
[8] Univ Ottawa, Dept Pediat, Div Pediat Endocrinol, Ottawa, ON, Canada
[9] Childrens Hosp Eastern Ontario Res Inst, Ottawa, ON, Canada
[10] Indiana Univ Sch Med, Dept Pediat, Div Pediat Endocrinol Diabetol, Indianapolis, IN USA
来源
HORMONE RESEARCH IN PAEDIATRICS | 2025年 / 98卷 / 01期
关键词
Rickets; Prematurity; Nutrition; Metabolic bone disease; Phosphate; BIRTH-WEIGHT INFANTS; SERUM ALKALINE-PHOSPHATASE; VITAMIN-D SUPPLEMENTATION; PRETERM INFANTS; PARATHYROID-HORMONE; DETECTING RICKETS; REFERENCE VALUES; CALCIUM; MINERALIZATION; OSTEOPENIA;
D O I
10.1159/000536228
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Metabolic bone disease of prematurity (MBDP) is defined by undermineralization of the preterm infant skeleton arising from inadequate prenatal and postnatal calcium (Ca) and phosphate (PO4) accretion. Severe MBDP can be associated with rickets and fractures. Despite advances in neonatal nutrition, MBDP remains prevalent in premature infants due to inadequate mineral accretion ex utero. There also remain significant knowledge gaps regarding best practices for monitoring and treatment of MBDP among neonatologists and pediatric endocrinologists. Preventing and treating MBDP can prevent serious consequences including rickets or pathologic fractures. Postnatal monitoring to facilitate early recognition of MBDP is best done by first-tier laboratory screening by measuring serum Ca, phosphorus, and alkaline phosphatase to identify infants at risk. If these laboratories are abnormal, further studies including assessing parathyroid hormone and/or tubular resorption of PO4 can help differentiate between Ca and PO4 deficiency as primary etiologies to guide appropriate treatment with mineral supplements. Additional research into optimal mineral supplementation for the prevention and treatment of MBDP is needed to improve long-term bone health outcomes and provide a fuller evidence base for future treatment guidelines.
引用
收藏
页码:40 / 50
页数:11
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