To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics

被引:3
作者
Kurganovs, Natalie Jayne [1 ]
Engedal, Nikolai [1 ]
机构
[1] Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Autophagy Canc Lab, Oslo, Norway
关键词
autophagy; prostate; cancer; carcinogenesis; therapy; androgen deprivation; radiation; chemotherapy; MITOXANTRONE PLUS PREDNISONE; PROTEIN-DEGRADATION; BIOCHEMICAL RECURRENCE; INDEPENDENT FUNCTIONS; ANDROGEN DEPRIVATION; SIGNALING PATHWAYS; CELL-LINES; RESISTANT; DOCETAXEL; LC3;
D O I
10.3389/fphar.2024.1419806
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Around 1 in 7 men will be diagnosed with prostate cancer during their lifetime. Many strides have been made in the understanding and treatment of this malignancy over the years, however, despite this; treatment resistance and disease progression remain major clinical concerns. Recent evidence indicate that autophagy can affect cancer formation, progression, and therapeutic resistance. Autophagy is an evolutionarily conserved process that can remove unnecessary or dysfunctional components of the cell as a response to metabolic or environmental stress. Due to the emerging importance of autophagy in cancer, targeting autophagy should be considered as a potential option in disease management. In this review, along with exploring the advances made on understanding the role of autophagy in prostate carcinogenesis and therapeutics, we will critically consider the conflicting evidence observed in the literature and suggest how to obtain stronger experimental evidence, as the application of current findings in clinical practice is presently not viable.
引用
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页数:22
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