To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics

被引:0
|
作者
Kurganovs, Natalie Jayne [1 ]
Engedal, Nikolai [1 ]
机构
[1] Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Autophagy Canc Lab, Oslo, Norway
关键词
autophagy; prostate; cancer; carcinogenesis; therapy; androgen deprivation; radiation; chemotherapy; MITOXANTRONE PLUS PREDNISONE; PROTEIN-DEGRADATION; BIOCHEMICAL RECURRENCE; INDEPENDENT FUNCTIONS; ANDROGEN DEPRIVATION; SIGNALING PATHWAYS; CELL-LINES; RESISTANT; DOCETAXEL; LC3;
D O I
10.3389/fphar.2024.1419806
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Around 1 in 7 men will be diagnosed with prostate cancer during their lifetime. Many strides have been made in the understanding and treatment of this malignancy over the years, however, despite this; treatment resistance and disease progression remain major clinical concerns. Recent evidence indicate that autophagy can affect cancer formation, progression, and therapeutic resistance. Autophagy is an evolutionarily conserved process that can remove unnecessary or dysfunctional components of the cell as a response to metabolic or environmental stress. Due to the emerging importance of autophagy in cancer, targeting autophagy should be considered as a potential option in disease management. In this review, along with exploring the advances made on understanding the role of autophagy in prostate carcinogenesis and therapeutics, we will critically consider the conflicting evidence observed in the literature and suggest how to obtain stronger experimental evidence, as the application of current findings in clinical practice is presently not viable.
引用
收藏
页数:22
相关论文
共 50 条
  • [1] Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review
    Loizzo, Davide
    Pandolfo, Savio Domenico
    Rogers, Devin
    Cerrato, Clara
    di Meo, Nicola Antonio
    Autorino, Riccardo
    Mirone, Vincenzo
    Ferro, Matteo
    Porta, Camillo
    Stella, Alessandro
    Bizzoca, Cinzia
    Vincenti, Leonardo
    Spilotros, Marco
    Rutigliano, Monica
    Battaglia, Michele
    Ditonno, Pasquale
    Lucarelli, Giuseppe
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (07)
  • [2] Corticosteroids in the Management of Prostate Cancer: A Critical Review
    Ndibe, Chukwuma
    Wang, Christopher G.
    Sonpavde, Guru
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2015, 16 (02)
  • [3] The evolving role of chemotherapy in prostate cancer
    Boulos, Suliman
    Mazhar, Danish
    FUTURE ONCOLOGY, 2017, 13 (12) : 1091 - 1095
  • [4] Role of taxanes in advanced prostate cancer
    Cassinello, J.
    Carballido Rodriguez, J.
    Anton Aparicio, L.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2016, 18 (10) : 972 - 980
  • [5] Oligometastatic prostate cancer: definition and the role of local and systemic therapy: a narrative review
    Mahjoub, Samy
    Heidenreich, Axel
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2021, 10 (07) : 3167 - 3175
  • [6] Local Therapeutics for the Treatment of Oligo Metastatic Prostate Cancer
    Jalfon, Michael J. J.
    Sakhalkar, Om V. V.
    Lokeshwar, Soum D. D.
    Marks, Victoria A. A.
    Choksi, Ankur U. U.
    Klaassen, Zachary
    Leapman, Michael S. S.
    Kim, Isaac Y. Y.
    CURRENT UROLOGY REPORTS, 2023, 24 (10) : 455 - 461
  • [7] Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer
    Eberli, Daniel
    Kranzbuhler, Benedikt
    Prause, Lukas
    Baumgartner, Valentin
    Preda, Sheryl
    Sousa, Rosa
    Lehner, Fabienne
    Salemi, Souzan
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022, 148 (12) : 3351 - 3360
  • [8] Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis
    Pal, Deeksha
    Suman, Suman
    Kolluru, Venkatesh
    Sears, Sophia
    Das, Trinath P.
    Alatassi, Houda
    Ankem, Murali K.
    Freedman, Jonathan H.
    Damodaran, Chendil
    BRITISH JOURNAL OF CANCER, 2017, 117 (01) : 56 - 64
  • [9] Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis
    Deeksha Pal
    Suman Suman
    Venkatesh Kolluru
    Sophia Sears
    Trinath P Das
    Houda Alatassi
    Murali K Ankem
    Jonathan H Freedman
    Chendil Damodaran
    British Journal of Cancer, 2017, 117 : 56 - 64
  • [10] Role of stroma in carcinogenesis of the prostate
    Cunha, GR
    Hayward, SW
    Wang, YZ
    DIFFERENTIATION, 2002, 70 (9-10) : 473 - 485