Metal-Free Synthesis of C-3-Alkoxycarbonylated 2 H -Indazoles Using Alkyl Carbazates

被引：2

作者：

Lai, Dipti ^{[1
,2
]}

Bhattacharjee, Suvam ^{[1
]}

Ghosh, Sumit ^{[1
,2
]}

Sinha, Subrata ^{[2
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

[2] Visva Bharati, Integrated Sci Educ & Res Ctr, Santini Ketan 731235, W Bengal, India

来源：

SYNLETT | 2024年 / 35卷 / 20期

关键词：

metal-free; C-3-alkoxycarbonylation; 2; H; -indazole; synthetic transformations; alkyl carbazate; PALLADIUM-CATALYZED CARBONYLATION; RADICAL ALKOXYCARBONYLATION; ESTERS; 2H-INDAZOLES; ARYL; ALKENES; ARYLALKOXYCARBONYLATION; DERIVATIVES; CONVERSION; HALIDES;

D O I：

10.1055/a-2316-5066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and environmentally benign method forthe direct C-3-alkoxycarbonylation of 2H-indazoles using alkyl carbaza-tes has been developed under metal-free conditions at room tempera-ture. This current protocol represents a facile access to C-3-carboxylicester derived 2H-indazoles with wide functional group tolerance ingood to excellent yields. The mechanistic studies suggest that the reac-tion proceeds through a radical pathway

引用

页码：2477 / 2481

页数：5

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