Isolation of a new iso-quinoline alkaloid and cytotoxicity studies of pure compounds and crude extracts of Ravenia spectabilis engl

被引：0

作者：

Tabassum, Fatema ^{[1
,2
]}

Islam, Sheikh Nazrul ^{[3
]}

Tuz-Zohora, Fatema ^{[4
]}

Hasan, Choudhury Mahmood ^{[1
]}

Rahman, Khondaker Miraz ^{[5
]}

Ahsan, Monira ^{[1
]}

机构：

[1] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh

[2] Stamford Univ Bangladesh, Dept Pharm, 51 Siddeswari Rd, Dhaka 1217, Bangladesh

[3] Univ Dhaka, Inst Nutr & Food Sci, Dhaka 1000, Bangladesh

[4] Univ Asia Pacific, Dept Pharm, 74-A Green Rd, Dhaka 1205, Bangladesh

[5] Kings Coll London, Sch Canc & Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England

来源：

HELIYON | 2024年 / 10卷 / 14期

关键词：

Ravenia spectabilis engl; 2-Quinolone alkaloid; iso-oligophyline; Triterpene; Cytotoxicity; Stomach cancer cell line; NATURAL-PRODUCTS; DRUG DISCOVERY;

D O I：

10.1016/j.heliyon.2024.e34508

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new 2-quinolone alkaloid, iso-oligophyline (1), and two very unusual C34 terpenoids, proposed names ravespanol (2) and ravespanone (3), along with two known compounds, beta-sitosterol (4), and methyl linoleate (5), were isolated from the leaf extract of Ravenia spectabilis engl. Methyl linoleate constitutes the first report of isolation from this species. We have already reported the isolation of atanine (6), oligophyline (7), ravenoline (8), and arborinine (9) from the plant. Based on nuclear magnetic resonance (NMR) spectroscopy and mass spectrometric analysis, the structure of the isolated chemicals was determined. The crude fractions and four compounds (6,7,8 and 9) were evaluated for a cytotoxicity study on a panel of six human stomach cancer cell lines (SCL, SCL-6, SCL-37 ' 6, SCL-9, K-3, N21) by MTT assay. Among the plant extracts and isolated compounds, petroleum ether fraction and compound 7 exhibited the highest cytotoxic activity against SCL and SCL-6 cells, where the IC50 values were 17.9 and 16.56 mu M, respectively.

引用

页数：9