Strategies to Regulate the Degradation and Clearance of Mesoporous Silica Nanoparticles: A Review

被引：0

作者：

Zhang, Yuelin ^{[1
]}

Lin, Xue ^{[1
]}

Chen, Xinxin ^{[1
]}

Fang, Weixiang ^{[1
]}

Yu, Kailing ^{[1
]}

Gu, Wenting ^{[1
]}

Wei, Yinghui ^{[1
]}

Zheng, Hangsheng ^{[1
]}

Piao, Jigang ^{[1
]}

Li, Fanzhu ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷

基金：

美国国家科学基金会;

关键词：

mesoporous silica nanoparticles; degradation; clearance; biodistribution; strategies; BRIDGED SILSESQUIOXANE FRAMEWORK; DRUG-DELIVERY; ORGANOSILICA NANOPARTICLES; CHARGE-REVERSAL; LIVER-CANCER; IN-VITRO; BIODISTRIBUTION; EXCRETION; NANOCARRIERS; NANOCAPSULES;

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Mesoporous silica nanoparticles (MSNs) have attracted extensive attention as drug delivery systems because of their unique meso-structural features (high specific surface area, large pore volume, and tunable pore structure), easily modified surface, high drugloading capacity, and sustained-release profiles. However, the enduring and non-specific enrichment of MSNs in healthy tissues may lead to toxicity due to their slow degradability and hinder their clinical application. The emergence of degradable MSNs provided a solution to this problem. The understanding of strategies to regulate degradation and clearance of these MSNs for promoting clinical trials and expanding their biological applications is essential. Here, a diverse variety of degradable MSNs regarding considerations of physiochemical properties and doping strategies of degradation, the biodistribution of MSNs in vivo, internal clearance mechanism, and adjusting physical parameters of clearance are highlighted. Finally, an overview of these degradable and clearable MSNs strategies for biosafety is provided along with an outlook of the encountered challenges.

引用

页码：5859 / 5878

页数：20

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