Molecular regulators of defective placental and cardiovascular development in fetal growth restriction

被引:1
|
作者
Umapathy, Anandita [1 ]
Clark, Alys [1 ,2 ]
Sehgal, Arvind [3 ,4 ]
Karanam, Vijaya [5 ,6 ]
Rajaraman, Gayathri [7 ]
Kalionis, Bill [5 ,6 ,8 ]
Jones, Helen N. [9 ,10 ]
James, Jo [1 ,2 ]
Murthi, Padma [5 ,6 ,8 ,11 ]
机构
[1] Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand
[2] Auckland Bioengn Inst, Bioengn Inst, Auckland, New Zealand
[3] Monash Univ, Dept Paediat, Melbourne, Vic, Australia
[4] Monash Childrens Hosp, Monash Newborn, Melbourne, Vic, Australia
[5] Univ Melbourne, Dept Obstet Gynaecol & Newborn Hlth, Melbourne, Vic, Australia
[6] Royal Womens Hosp, Parkville, Vic, Australia
[7] Victoria Univ, Year Coll 1, St Albans, Vic 3021, Australia
[8] Royal Womens Hosp, Pregnancy Res Ctr, Dept Maternal Fetal Med, Parkville, Vic, Australia
[9] Univ Florida, Coll Med, Dept Physiol & Aging, Gainesville, FL USA
[10] Univ Florida, Coll Med, Ctr Res Perinatal Outcomes, Gainesville, FL USA
[11] Monash Univ, Biomed Discovery Inst, Dept Pharmacol, Clayton, Vic, Australia
关键词
MESENCHYMAL STROMAL CELLS; BHLH TRANSCRIPTION FACTOR; GESTATIONAL-AGE FETUSES; ENDOTHELIAL-CELLS; UMBILICAL ARTERY; HOMEOBOX GENES; CARDIAC DEVELOPMENT; VASCULAR FUNCTION; NORMAL-PREGNANCY; EMBRYOS LACKING;
D O I
10.1042/CS20220428
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born too small, affected offspring are at increased risk of cardiovascular disease, diabetes and other chronic diseases in later life. The placenta and heart develop concurrently, therefore placental maldevelopment and function in FGR may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic molecules and transcription factors that are common causes of defective placental and cardiovascular development.
引用
收藏
页码:761 / 775
页数:15
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