Oligoclonal bands

被引：3

作者：

Willis, Mark D. ^{[1
]}

Kreft, Karim L. ^{[1
]}

Dancey, Bethan ^{[2
]}

机构：

[1] Univ Hosp Wales, Helen Durham Ctr Neuroinflammatory Dis, Dept Neurol, Cardiff, Wales

[2] Univ Hosp Wales, Dept Clin Immunol & Allergy, Cardiff, Wales

来源：

PRACTICAL NEUROLOGY | 2024年 / 24卷 / 05期

关键词：

neuroimmunology; multiple sclerosis; CEREBROSPINAL-FLUID FINDINGS; MULTIPLE-SCLEROSIS; IMMUNOGLOBULIN-G; IGG SYNTHESIS; CSF ANALYSIS; DIAGNOSIS; DISEASES; SERUM; NEUROSARCOIDOSIS; ANTIBODIES;

D O I：

10.1136/pn-2023-003814

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oligoclonal bands (OCBs) represent the presence of intrathecal immunoglobulin G (IgG) as detected by isoelectric focusing and immunofixation. Cerebrospinal fluid (CSF) analysed alongside a paired serum sample gives five different immunofixation patterns. These are: type 1-the normal physiological state with no intrathecal IgG synthesis; type 2-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs; type 3-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs, but with additional, identical bands in the CSF and serum; type 4-absence of intrathecal IgG synthesis, but with identical OCBs in CSF and serum; and type 5-absence of intrathecal IgG synthesis, with a monoclonal band in CSF and serum. Analysis of these patterns can help to diagnose a range of neurological conditions, including multiple sclerosis. However, it is important to interpret OCB results alongside other CSF tests and their clinical context.

引用

页数：8

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