Dengue virus transmission risk in blood donation: Evidence from Thailand

被引：3

作者：

Limothai, Umaporn ^{[1
,2
,3
]}

Tachaboon, Sasipha ^{[1
,2
,3
]}

Dinhuzen, Janejira ^{[1
,2
,3
]}

Singh, Jasleen ^{[3
,4
,5
]}

Leewongworasingh, Akarathep ^{[1
,2
,3
]}

Watanaboonyongcharoen, Phandee ^{[6
,7
]}

Fernandez, Stefan ^{[8
]}

Hunsawong, Taweewun ^{[8
]}

Farmer, Aaron R. ^{[8
]}

Tantawichien, Terapong ^{[3
,9
]}

Thisyakorn, Usa ^{[3
]}

Srisawat, Nattachai ^{[1
,2
,3
,10
,11
,12
]}

机构：

[1] King Chulalongkorn Mem Hosp, Excellence Ctr Crit Care Nephrol, Bangkok, Thailand

[2] Chulalongkorn Univ, Fac Med, Ctr Excellence Crit Care Nephrol, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Trop Med Cluster, Bangkok, Thailand

[4] Chulalongkorn Univ, Fac Med, Sch Global Hlth, Bangkok, Thailand

[5] Hlth Educ England, Thailand Publ Hlth Res Fellowship, London, England

[6] Chulalongkorn Univ, Fac Med, Dept Lab Med, Bangkok, Thailand

[7] King Chulalongkorn Mem Hosp, Transfus Med Unit, Bangkok, Thailand

[8] Armed Forces Res Inst Med Sci AFRIMS, Dept Virol, Bangkok, Thailand

[9] Chulalongkorn Univ, Fac Med, Dept Med, Div Infect Dis, Bangkok, Thailand

[10] King Chulalongkorn Mem Hosp, Fac Med, Dept Med, Div Nephrol, Bangkok, Thailand

[11] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Ctr Crit Care Nephrol,CRISMA Ctr, Pittsburgh, PA USA

[12] Royal Soc Thailand, Acad Sci, Bangkok, Thailand

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 06期

关键词：

acute dengue virus infection; asymptomatic infections; dengue virus infection; healthy blood donors; Thailand; transfusion transmission; VIREMIA; PCR; INFECTION; THREAT; DONORS;

D O I：

10.1002/jmv.29689

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Individuals infected with dengue virus (DENV) often show no symptoms, which raises the risk of DENV transfusion transmission (TT-DENV) in areas where the virus is prevalent. This study aimed to determine the evidence of DENV infection in blood donors from different geographic regions of Thailand. A cross-sectional study was conducted on blood donor samples collected from the Thai Red Cross National Blood Center and four regional blood centers between March and September 2020. Screening for DENV nonstructural protein 1 (NS1), anti-DENV immunoglobulin G (IgG), and IgM antibodies was performed on residual blood from 1053 donors using enzyme-linked immunosorbent assay kits. Positive NS1 and IgM samples indicating acute infection were verified using four different techniques, including quantitative real-time (q) RT-PCR, nested PCR, virus isolation in C6/36 cells, and mosquito amplification. DENV IgG seropositivity was identified in 89% (938/1053) of blood donors. Additionally, 0.4% (4/1053) and 2.1% (22/1053) of Thai blood donors tested positive for NS1 and IgM, respectively. The presence of asymptomatic dengue virus infection in healthy blood donors suggests a potential risk of transmission through blood transfusion, posing a concern for blood safety.

引用

页数：10

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