The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response

被引：9

作者：

Guo, Xuanyu ^{[1
]}

Song, Jiajun ^{[2
]}

Liu, Miao ^{[3
]}

Ou, Xinyi ^{[3
]}

Guo, Yongcan ^{[3
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Clin Lab Med, Luzhou, Peoples R China

[3] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Clin Lab, Key Lab Luzhou,Nanobiosensing & Microfluid Point o, 182 Chunhui Rd, Luzhou 646000, Peoples R China

来源：

CANCER BIOLOGY & THERAPY | 2024年 / 25卷 / 01期

关键词：

Tumor microenvironment; tumor-derived small extracellular vesicles; hypoxic microenvironment; acidic microenvironment; immunosuppressive microenvironment; targeted therapy; RENAL-CELL CARCINOMA; SUPPRESSOR-CELLS; EXOSOME SECRETION; IMMUNE-RESPONSES; MOUSE MODELS; HEXOKINASE; HYPOXIA; MACROPHAGES; BIOGENESIS; INHIBITION;

D O I：

10.1080/15384047.2024.2356831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released by all cell types and often reflect the state of their parental cells and modulate other cells' functions through the various cargo they transport. Tumor-derived small EVs (TDSEVs) can transport specific proteins, nucleic acids and lipids tailored to propagate tumor signals and establish a favorable TME. Thus, the TME's biological characteristics can affect TDSEV heterogeneity, and this interplay can amplify tumor growth, dissemination, and resistance to therapy. This review discusses the interplay between TME and TDSEVs based on their biological characteristics and summarizes strategies for targeting cancer cells. Additionally, it reviews the current issues and challenges in this field to offer fresh insights into comprehending tumor development mechanisms and exploring innovative clinical applications.

引用

页数：23

共 259 条

[1] NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes [J].

Adams, Drew J. ;

Ito, Daisuke ;

Rees, Matthew G. ;

Seashore-Ludlow, Brinton ;

Puyang, Xiaoling ;

Ramos, Alex H. ;

Cheah, Jaime H. ;

Clemons, Paul A. ;

Warmuth, Markus ;

Zhu, Ping ;

Shamji, Alykhan F. ;

Schreiber, Stuart L. .

ACS CHEMICAL BIOLOGY, 2014, 9 (10) :2247-2254

[2] Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation [J].

Airola, Michael V. ;

Shanbhogue, Prajna ;

Shamseddine, Achraf A. ;

Guja, Kip E. ;

Senkal, Can E. ;

Maini, Rohan ;

Bartke, Nana ;

Wu, Bill X. ;

Obeid, Lina M. ;

Garcia-Diaz, Miguel ;

Hannun, Yusuf A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (28) :E5549-E5558

[3] Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer [J].

Ali, Khaled ;

Soond, Dalya R. ;

Pineiro, Roberto ;

Hagemann, Thorsten ;

Pearce, Wayne ;

Lim, Ee Lyn ;

Bouabe, Hicham ;

Scudamore, Cheryl L. ;

Hancox, Timothy ;

Maecker, Heather ;

Friedman, Lori ;

Turner, Martin ;

Okkenhaug, Klaus ;

Vanhaesebroeck, Bart .

NATURE, 2014, 510 (7505) :407-+

[4] Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells [J].

Alissafi, Themis ;

Hatzioannou, Aikaterini ;

Mintzas, Konstantinos ;

Barouni, Roza Maria ;

Banos, Aggelos ;

Sormendi, Sundary ;

Polyzos, Alexandros ;

Xilouri, Maria ;

Wielockx, Ben ;

Gogas, Helen ;

Verginis, Panayotis .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (09) :3840-3852

[5] Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics [J].

Alshetaiwi, Hamad ;

Pervolarakis, Nicholas ;

McIntyre, Laura Lynn ;

Ma, Dennis ;

Quy Nguyen ;

Rath, Jan Akara ;

Nee, Kevin ;

Hernandez, Grace ;

Evans, Katrina ;

Torosian, Leona ;

Silva, Anushka ;

Walsh, Craig ;

Kessenbrock, Kai .

SCIENCE IMMUNOLOGY, 2020, 5 (44)

[6] Exosomes from plasmacytoma cells as a tumor vaccine [J].

Altieri, SL ;

Khan, ANH ;

Tomasi, TB .

JOURNAL OF IMMUNOTHERAPY, 2004, 27 (04) :282-288

[7] Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses [J].

Anfray, Clement ;

Ummarino, Aldo ;

Torres Andon, Fernando ;

Allavena, Paola .

CELLS, 2020, 9 (01)

[8]

Antonyak Marc A, 2012, Small GTPases, V3, P219, DOI 10.4161/sgtp.20755

[9] Oxidative Phosphorylation as an Emerging Target in Cancer Therapy [J].

Ashton, Thomas M. ;

McKenna, W. Gillies ;

Kunz-Schughart, Leoni A. ;

Higgins, Geoff S. .

CLINICAL CANCER RESEARCH, 2018, 24 (11) :2482-2490

[10] Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis [J].

Bai, Suwen ;

Wang, Zunyun ;

Wang, Minghua ;

Li, Junai ;

Wei, Yuan ;

Xu, Ruihuan ;

Du, Juan .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10

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