Co-Infection of SARS-CoV-2 and Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

被引:1
作者
das Chagas, Angelica de Lima [1 ]
Araujo, Joilma Cruz da Silva [2 ]
Serra, Jaqueline Correia Pontes [1 ]
de Araujo, Kelliane Martins [1 ]
Cunha, Marcos de Oliveira [1 ]
Correia, Amanda dos Reis [1 ]
Goncalves, Laura Maria Barbosa [3 ]
Carneiro, Lilian Carla [1 ]
机构
[1] Univ Fed Goias, Hlth Sci Post Grad, BR-74605050 Goiania, GO, Brazil
[2] Univ Fed Goias, Pharm Fac, BR-74605170 Goiania, GO, Brazil
[3] Univ Fed Goias, Postgrad Program Biol Host Parasite Relationship, Goiania, GO, Brazil
关键词
bacterium; epidemiology; virology; COVID-19; PATIENTS; ANTIBIOTICS; RESISTANCE; INFECTION;
D O I
10.3390/diagnostics14111149
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The study aimed to assess the prevalence of COVID-19 and Klebsiella spp. coinfection across continents. Conducted following PRISMA guidelines, a systematic review utilized PubMed, Embase, SCOPUS, ScienceDirect, and Web of Science databases, searching for literature in English published from December 2019 to December 2022, using specific Health Sciences descriptors. A total of 408 records were identified, but only 50 were eligible, and of these, only 33 were included. Thirty-three references were analyzed to evaluate the correlation between COVID-19 and Klebsiella spp. infections. The tabulated data represented a sample group of 8741 coinfected patients. The findings revealed notable disparities in co-infection rates across continents. In Asia, 23% of individuals were infected with Klebsiella pneumoniae, while in Europe, the proportion of co-infected patients stood at 15%. Strikingly, on the African continent, 43% were found to be infected with Klebsiella pneumoniae, highlighting significant regional variations. Overall, the proportion of Klebsiella pneumoniae co-infections among COVID-positive individuals were determined to be 19%. Particularly concerning was the observation that 1 in 6 ICU coinfections was attributed to Klebsiella pneumoniae, indicating its substantial impact on patient outcomes and healthcare burden. The study underscores the alarming prevalence of co-infection between COVID-19 and Klebsiella pneumoniae, potentially exacerbating the clinical severity of patients and posing challenges to treatment strategies. These findings emphasize the importance of vigilant surveillance and targeted interventions to mitigate the adverse effects of bacterial coinfections in the context of the COVID-19 pandemic.
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页数:14
相关论文
共 69 条
[21]   Pulmonary bacterial infections in adult patients hospitalized for COVID-19 in standard wards [J].
Husain, M. ;
Valayer, S. ;
Poey, N. ;
Rondinaud, E. ;
d'Humieresd, C. ;
Visseaux, B. ;
Lariven, S. ;
Lescure, F. X. ;
Deconinck, L. .
INFECTIOUS DISEASES NOW, 2022, 52 (04) :208-213
[22]   Profile of co-infections & secondary infections in COVID-19 patients at a dedicated COVID-19 facility of a tertiary care Indian hospital: Implication on antimicrobial resistance [J].
Khurana, Surbhi ;
Singh, Parul ;
Sharad, Neha ;
Kiro, Vandana V. ;
Rastogi, Neha ;
Lathwal, Amit ;
Malhotra, Rajesh ;
Trikha, Anjan ;
Mathur, Purva .
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2021, 39 (02) :147-153
[23]   Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents? [J].
Lai, Chih-Cheng ;
Wang, Cheng-Yi ;
Hsueh, Po-Ren .
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2020, 53 (04) :505-512
[24]   Co-infections in people with COVID-19: a systematic review and meta-analysis [J].
Lansbury, Louise ;
Lim, Benjamin ;
Baskaran, Vadsala ;
Lim, Wei Shen .
JOURNAL OF INFECTION, 2020, 81 (02) :266-275
[25]   Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19 [J].
Ma, Shengli ;
Zhang, Fan ;
Zhou, Fengxia ;
Li, Hui ;
Ge, Wenyu ;
Gan, Rui ;
Nie, Huan ;
Li, Biao ;
Wang, Yindong ;
Wu, Meng ;
Li, Duo ;
Wang, Dongmei ;
Wang, Zheng ;
You, Yuhong ;
Huang, Zhiwei .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[26]   Bacterial co-infections and antibiotic resistance in patients with COVID-19 [J].
Mahmoudi, Hassan .
GMS HYGIENE AND INFECTION CONTROL, 2020, 15
[27]  
Maral T.V.G., 2021, Sade Coletiva, V11, P5174, DOI [10.36489/saudecoletiva.2021v11i62p5174-5191, DOI 10.36489/SAUDECOLETIVA.2021V11I62P5174-5191]
[28]   Does the COVID Pandemic Modify the Antibiotic Resistance of Uropathogens in Female Patients? A New Storm? [J].
Mares, Cristian ;
Petca, Razvan-Cosmin ;
Petca, Aida ;
Popescu, Razvan-Ionut ;
Jinga, Viorel .
ANTIBIOTICS-BASEL, 2022, 11 (03)
[29]  
Marua Alpesh M, 2022, Maedica (Bucur), V17, P350, DOI 10.26574/maedica.2022.17.2.350
[30]   Respiratory Microbial Co-infection With SARS-CoV-2 [J].
Massey, Bill W. ;
Jayathilake, Karuna ;
Meltzer, Herbert Y. .
FRONTIERS IN MICROBIOLOGY, 2020, 11