Formulation and Evaluation of Olmesartan Medoxomil Tablets

被引:4
作者
Gonzalez, Rocio [1 ]
Pena, Maria angeles [1 ]
Torrado, Guillermo [1 ]
机构
[1] Univ Alcala UAH, Fac Pharm, Dept Biomed Sci, E-28871 Alcala De Henares, Madrid, Spain
来源
COMPOUNDS | 2022年 / 2卷 / 04期
关键词
olmesartan medoxomil; preformulation; tablet; physicochemical characterization; PHYSICOCHEMICAL CHARACTERIZATION; SEDEM DIAGRAM; COMPATIBILITY; MANAGEMENT; DESIGN;
D O I
10.3390/compounds2040028
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This work proposes a methodology for the design, development, and characterization of tablets prepared by the direct compression method of olmesartan medoxomil. The main objective was to ensure a high dissolution rate of the active ingredient. Therefore, a rigorous selection of excipients was carried out to ensure their physical and chemical compatibility with the active ingredient by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FT-IR) studies. The suitability of the mixture for use in direct compression was performed using SeDeM methodology. The tablets met pharmacopoeia specifications for content uniformity, breaking strength, friability, and disintegration time.
引用
收藏
页码:334 / 352
页数:19
相关论文
共 52 条
[11]   Key aspects of analytical method validation and linearity evaluation [J].
Araujo, Pedro .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (23) :2224-2234
[12]  
Audibert J.Y., 2011, Ann Stat, DOI [10.1214/11-AOS918.full, DOI 10.1214/11-AOS918.FULL]
[13]  
Bazzo Giovana Carolina, 2005, Revista Brasileira de Ciencias Farmaceuticas, V41, P315
[14]   TABLETING PROPERTIES OF EXPERIMENTAL AND COMMERCIALLY AVAILABLE LACTOSE GRANULATIONS FOR DIRECT COMPRESSION [J].
BOLHUIS, GK ;
ZUURMAN, K .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1995, 21 (18) :2057-2071
[15]  
Carrasco L., 2013, Doctoral Thesis
[16]   Drug-excipient compatibility screening-Role of thermoanalytical and spectroscopic techniques [J].
Chadha, Renu ;
Bhandari, Swati .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 87 :82-97
[17]   A multi-analyte LC-MS/MS method for screening and quantification of nitrosamines in sartans [J].
Chang, Shu-Han ;
Chang, Ching-Chia ;
Wang, Li-Jing ;
Chen, Wei-Ching ;
Fan, Shu-Yu ;
Zang, Chi-Zong ;
Hsu, Ya-Hui ;
Lin, Mei-Chih ;
Tseng, Su-Hsiang ;
Wang, Der-Yuan .
JOURNAL OF FOOD AND DRUG ANALYSIS, 2020, 28 (02) :98-107
[18]  
Clavijo J, 2013, ELEMENTOS, V3, P133, DOI 10.15765/e.v3i3.420
[19]  
Davies P., 2009, Pharmaceutical preformulation and formulation: a practical guide from candidate drug selection to commercial dosage form
[20]   SeDeM expert system a new innovator tool to develop pharmaceutical forms [J].
Edward Aguilar-Diaz, Johnny ;
Garcia-Montoya, Encarna ;
Perez-Lozano, Pilar ;
Maria Sune-Negre, Jose ;
Minarro, Montserrat ;
Tico, Jose Ramon .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2014, 40 (02) :222-236