Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules

Piperazine and thiazole moieties are commonly found in medicines and bioactive compounds. One of the fruitful ways in drug design is the hybridization of privilege structures in one skeleton, which are thought to provide a distinguishing feature with better or more selective biological activities than the two scaffolds. In this study, a series of bis-thiazoles, linked to piperazine as novel hybrid molecules, were synthesized in good yields by reacting the appropriate alpha-halo ketones or alpha-keto-hydrazonoyl chlorides with the corresponding piperazine bis(hydrazinecarbothioamide) in EtOH/DMF at reflux, in the presence of a few drops of TEA. The initial bis-thiosemicarbazones were formed by reacting the appropriate bis-aldehyde or bis-ethanone with thiosemicarbazide in EtOH with a few drops of AcOH at reflux. The novel compounds' structures were validated using elemental analysis and spectrum data.