Intraoperative radiotherapy in soft tissue sarcomas of the extremities and retroperitoneum: review of the evidence and therapeutic approach at the Instituto Nacional de Cancerología, Colombia

Soft tissue sarcomas are low -incidence tumors, representing 1% of malignant tumors in adults (1). Surgery is the mainstay of treatment, with curative intent; nevertheless, due to the high risk of local recurrence, other multimodal treatment strategies have been used, both neoadjuvant and adjuvant. Intraoperative radiotherapy is an alternative that has been used in conjunction with neoadjuvant or adjuvant radiation therapy. Given that there are no controlled clinical trials that respond to the benefit of intraoperative radiotherapy in the management of patients with soft tissue sarcomas of the extremities and retroperitoneum, a literature review was conducted on the evidence of intraoperative radiotherapy in local control, overall survival, disease-free survival, and safety, in order to establish precise indications for intraoperative radiotherapy in patients with soft tissue sarcomas located in the extremities and retroperitoneum at the Instituto Nacional de Cancerologia (Bogota, Colombia).