Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility

被引:9
作者
Omidvar-Mehrabadi, Alireza [1 ]
Ebrahimi, Fateme [1 ]
Shahbazi, Mehdi [1 ]
Mohammadnia-Afrouzi, Mousa [1 ]
机构
[1] Babol Univ Med Sci, Sch Med, Dept Immunol, Babol, Iran
关键词
Unexplained Infertility(UI); Polycystic Ovary Syndrome (PCOS); Endometriosis (EMS); Cytokines; Chemokines; ENDOTHELIAL GROWTH-FACTOR; PERITONEAL-FLUID CONCENTRATIONS; MONOCYTE CHEMOTACTIC PROTEIN-1; GAMMA-INDUCIBLE PROTEIN-10; MESSENGER-RNA EXPRESSION; IN-VITRO FERTILIZATION; NECROSIS-FACTOR-ALPHA; MATRIX METALLOPROTEINASES; INFLAMMATORY CYTOKINES; STROMAL CELLS;
D O I
10.1016/j.cyto.2024.156588
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conceive for no known reason. Conception and pregnancy are significantly affected by the immune system; in this regard, chemokines and cytokines play important roles in the regulation of immune responses. Patients with PCOS, EMS, and UI have altered cytokine and chemokine profiles, suggesting that dysregulation of these molecules may contribute to infertility in these conditions. Accordingly, the issue of infertility is addressed in this review study, a condition that affects approximately 16% of couples worldwide.
引用
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页数:15
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