Recent progress for chiral stationary phases based on chiral porous materials in high-performance liquid chromatography and gas chromatography separation

被引：2

作者：

Wang, Zhen ^{[1
]}

Wang, Wei ^{[1
]}

Luo, Ai-Qin ^{[1
]}

Yuan, Li-Ming ^{[2
]}

机构：

[1] Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, 5 Zhongguancun South St, Beijing 100081, Peoples R China

[2] Yunnan Normal Univ, Dept Chem, Kunming 650500, Peoples R China

来源：

JOURNAL OF SEPARATION SCIENCE | 2024年 / 47卷 / 13期

基金：

中国国家自然科学基金;

关键词：

chiral porous crystal materials; enantioseparation; post-modification; resolution; stationary phases; COVALENT ORGANIC FRAMEWORKS; CAGE COMPOUNDS; CRYSTALLINE; CHEMISTRY; CATALYSIS; CONSTRUCTION; COMPOSITE; DESIGN; HOST; MICROSPHERES;

D O I：

10.1002/jssc.202400073

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chirality is a fundamental property of nature. Separation and analysis of racemates are of great importance in the fields of medicine and the production of chiral biopharmaceutical intermediates. Chiral chromatography has the characteristics of a wide separation range, fast separation speed, and high efficiency. The development and preparation of novel chiral stationary phases with good chiral recognition and separation capacity is the core and key of chiral chromatographic separation and analysis. In this work, the representative research progress of novel chiral porous crystal materials including chiral covalent organic frameworks, chiral porous organic cages, chiral metal-organic frameworks, and chiral metal-organic cages used as chiral stationary phases of capillary gas chromatography and high-performance liquid chromatography over the last 4 years is reviewed in detail. The chiral recognition and separation properties of the representative studies in this review are also introduced and discussed.

引用

页数：16

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