Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

被引:1
作者
Elemam, Noha M. [1 ,2 ]
Hotait, Hassan Youssef [3 ]
Saleh, Mohamed A. [1 ,2 ,4 ]
El-Huneidi, Waseem [2 ,5 ]
Talaat, Iman M. [1 ,2 ,6 ]
机构
[1] Univ Sharjah, Coll Med, Clin Sci Dept, Sharjah, U Arab Emirates
[2] Univ Sharjah, Res Inst Med & Hlth Sci, Sharjah, U Arab Emirates
[3] Dubai Hosp, Pathol & Genet Dept, Dubai, U Arab Emirates
[4] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt
[5] Univ Sharjah, Coll Med, Basic Med Sci Dept, Sharjah, U Arab Emirates
[6] Alexandria Univ, Fac Med, Pathol Dept, Alexandria, Egypt
关键词
prostate cancer; IGF-I; IGF-II; IGF-1; receptor; IGF-2; FACTOR-I RECEPTOR; FACTOR-BINDING PROTEIN-2; II/MANNOSE 6-PHOSPHATE RECEPTOR; COMBINED IMMUNODEFICIENT MICE; HORMONE-RELEASING-HORMONE; PROGRAMMED CELL-DEATH; INHIBITS TUMOR-GROWTH; FACTOR-C EXPRESSION; IGF-I; ANDROGEN RECEPTOR;
D O I
10.3389/fendo.2024.1396192
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF-II receptor (IGF-2R)), and six IGF-binding proteins (IGFBPs). IGF-I and IGF-II were identified as potent mitogens and were previously associated with an increased risk of cancer development including prostate cancer. Several reports showed controversy about the expression of the IGF family and their connection to prostate cancer risk due to the high degree of heterogeneity among prostate tumors, sampling bias, and evaluation techniques. Despite that, it is clear that several IGF family members play a role in prostate cancer development, metastasis, and androgen-independent progression. In this review, we aim to expand our understanding of prostate tumorigenesis and regulation through the IGF system. Further understanding of the role of IGF signaling in PCa shows promise and needs to be considered in the context of a comprehensive treatment strategy.
引用
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页数:14
相关论文
共 240 条
[1]   Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage [J].
Aleksic, Tamara ;
Gray, Nicki ;
Wu, Xiaoning ;
Rieunier, Guillaume ;
Osher, Eliot ;
Mills, Jack ;
Verrill, Clare ;
Bryant, Richard J. ;
Han, Cheng ;
Hutchinson, Kathryn ;
Lambert, Adam G. ;
Kumar, Rajeev ;
Hamdy, Freddie C. ;
Weyer-Czernilofsky, Ulrike ;
Sanderson, Michael P. ;
Bogenrieder, Thomas ;
Taylor, Stephen ;
Macaulay, Valentine M. .
CANCER RESEARCH, 2018, 78 (13) :3497-3509
[2]   IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? [J].
Allard, John B. ;
Duan, Cunming .
FRONTIERS IN ENDOCRINOLOGY, 2018, 9
[3]   Prostate cancer: a tale of two sides [J].
不详 .
NATURE REVIEWS UROLOGY, 2019, 16 (03) :141-141
[4]  
Bach Leon A, 2004, Clin Biochem Rev, V25, P155
[5]  
BACHRACH LK, 1995, GROWTH REGULAT, V5, P109
[6]   IGF-I, insulin and prostate cancer [J].
Balarini Lima, Giovanna A. ;
Correa, Livia L. ;
Gabrich, Rafael ;
de Miranda, Luiz Carlos D. ;
Gadelha, Monica R. .
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2009, 53 (08) :969-975
[7]   A phase 2 study of OSI-906 (linsitinib, an insulin-like growth factor receptor-1 inhibitor) in patients with asymptomatic or mildly symptomatic (non-opioid requiring) metastatic castrate resistant prostate cancer (CRPC) [J].
Barata, Pedro ;
Cooney, Matthew ;
Tyler, Allison ;
Wright, John ;
Dreicer, Robert ;
Garcia, Jorge A. .
INVESTIGATIONAL NEW DRUGS, 2018, 36 (03) :451-457
[8]   MAMMARY-CANCER IN TRANSGENIC MICE EXPRESSING INSULIN-LIKE GROWTH-FACTOR-II (IGF-II) [J].
BATES, P ;
FISHER, R ;
WARD, A ;
RICHARDSON, L ;
HILL, DJ ;
GRAHAM, CF .
BRITISH JOURNAL OF CANCER, 1995, 72 (05) :1189-1193
[9]   Antiproliferative and pro-apoptotic activities of insulin-like growth factor-binding protein-3 [J].
Baxter, RC ;
Butt, AJ ;
Schedlich, LJ ;
Martin, JL .
GROWTH HORMONE & IGF RESEARCH, 2000, 10 :S10-S11
[10]   Signaling Pathways of the Insulin-like Growth Factor Binding Proteins [J].
Baxter, Robert C. .
ENDOCRINE REVIEWS, 2023, 44 (05) :753-778