Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria

被引：8

作者：

Wang, Hanfei ^{[1
,2
]}

Yang, Yingying ^{[1
,2
]}

Wang, Simeng ^{[1
,2
]}

Badawy, Sara ^{[3
,4
]}

Ares, Irma ^{[5
,6
]}

Martinez, Marta ^{[5
,6
]}

Lopez-Torres, Bernardo ^{[5
,6
]}

Martinez-Larranaga, Maria-Rosa ^{[5
,6
]}

Wang, Xu ^{[1
,2
,3
]}

Anadon, Arturo ^{[5
,6
]}

Martinez, Maria-Aranzazu ^{[5
,6
]}

机构：

[1] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China

[2] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China

[3] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China

[4] Benha Univ, Fac Vet Med, Pathol Dept Anim Med, Banha, Egypt

[5] Univ Complutense Madrid UCM, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain

[6] Res Inst Hosp 12 De Octubre I 12, Madrid 28040, Spain

来源：

JOURNAL OF CONTROLLED RELEASE | 2024年 / 369卷

基金：

中国国家自然科学基金;

关键词：

Multidrug-resistant bacteria; Antibiotic adjuvant; Antimicrobial sensitizer; Indirect antibacterial; GRAM-NEGATIVE BACTERIA; 3 POSITIVE CHARGES; PSEUDOMONAS-AERUGINOSA; ANTIBIOTIC-RESISTANCE; CLAVULANIC ACID; BETA-LACTAM; IN-VITRO; PEPTIDES; 4-HYDROXYBENZALDEHYDE; SUSCEPTIBILITY;

D O I：

10.1016/j.jconrel.2024.03.031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued development of new antibiotics and antibacterial agents, but the high costs and long timeframe involved in the development of new agents renders the hope that existing antibiotics may again play a part. The "antibiotic adjuvant" is an indirect antibacterial strategy, but its vague concept has, in the past, limited the development speed of related drugs. In this review article, we put forward an accurate concept of a "non-self-antimicrobial sensitisers (NSAS)", to distinguish it from an "antibiotic adjuvant", and then discuss several scientific methods to restore bacterial sensitivity to antibiotics, and the sources and action mechanism of existing NSAS, in order to guide the development and further research of NSAS.

引用

页码：25 / 38

页数：14

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